{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:47:42Z","timestamp":1785257262257,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2019A610355"],"award-info":[{"award-number":["2019A610355"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["LQ19F010003"],"award-info":[{"award-number":["LQ19F010003"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural and Science Fund","award":["2019A610355"],"award-info":[{"award-number":["2019A610355"]}]},{"name":"Zhejiang Provincial Natural and Science Fund","award":["LQ19F010003"],"award-info":[{"award-number":["LQ19F010003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2020,9,24]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Retina abnormalities are related to cognitive disorders in patients with Alzheimer\u2019s disease (AD). Retinal amyloid beta (A<jats:italic>\u03b2<\/jats:italic>) can be labeled by curcumin. We measured A<jats:italic>\u03b2<\/jats:italic> content in the cerebrum and retina of APPswe\/PS1dE9 (APP) transgenic mice with early age to investigate the correlation between cerebrum and retina. <jats:italic>Methods<\/jats:italic>. APP mice and age-matched wild-type mice were investigated every month from age 2 months to 6 months to assess changes in A<jats:italic>\u03b2<\/jats:italic> content in the retina and cerebrum. At the beginning of each month, mice were fed a curcumin diet (50\u2009mg\/kg\/day) for 7 consecutive days. The A<jats:italic>\u03b2<\/jats:italic> levels in the retina and cerebrum were measured by ELISAs. Correlations were identified between retinal and cerebral A<jats:italic>\u03b2<\/jats:italic> contents using Pearson\u2019s correlation. <jats:italic>Results<\/jats:italic>. In the absence of curcumin, there was a significant correlation between A<jats:italic>\u03b2<\/jats:italic> contents in the retina and cerebrum of APP mice (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.7291<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0014<\/mml:mn><\/mml:math>). With increasing age, A<jats:italic>\u03b2<\/jats:italic>-mediated degenerative change in the cerebrum (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math> in 5 months) and retina (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math> in 5 months) increased significantly. The inhibitory effect of curcumin on the A<jats:italic>\u03b2<\/jats:italic> level was significant in the cerebrum (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and retina (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) of older APP mice in the early stage of life. <jats:italic>Conclusion<\/jats:italic>. We observed a significant correlation between the A<jats:italic>\u03b2<\/jats:italic> content in the retina and A<jats:italic>\u03b2<\/jats:italic> content in the cerebrum of APP mice. Our data suggest an appropriate time to measure retinal A<jats:italic>\u03b2<\/jats:italic>. Although curcumin can label A<jats:italic>\u03b2<\/jats:italic> in the retina, it also suppresses A<jats:italic>\u03b2<\/jats:italic> levels and weakens the degree of correlation between A<jats:italic>\u03b2<\/jats:italic> in cerebrum and retina tissues.<\/jats:p>","DOI":"10.1155\/2020\/1574816","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T23:31:15Z","timestamp":1600990275000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Retinal Levels of Amyloid Beta Correlate with Cerebral Levels of Amyloid Beta in Young APPswe\/PS1dE9 Transgenic Mice before Onset of Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-8747","authenticated-orcid":true,"given":"Xi","family":"Mei","sequence":"first","affiliation":[{"name":"Kangning Hospital of Ningbo, Ningbo City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Ningbo University, Ningbo City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhu","sequence":"additional","affiliation":[{"name":"Weifang Medical University, Weifang City, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Kangning Hospital of Ningbo, Ningbo City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Li","sequence":"additional","affiliation":[{"name":"Kangning Hospital of Ningbo, Ningbo City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Chen","sequence":"additional","affiliation":[{"name":"Kangning Hospital of Ningbo, Ningbo City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-1037","authenticated-orcid":true,"given":"Chenjun","family":"Zou","sequence":"additional","affiliation":[{"name":"Kangning Hospital of Ningbo, Ningbo City, Zhejiang Province, 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