{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:51:00Z","timestamp":1781304660892,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005601","name":"University of Ghana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Ethnopharmacological Relevance<\/jats:italic>. Development of resistance to antimalarial drugs by <jats:italic>Plasmodium falciparum<\/jats:italic> is still rampant, and there is an urgent need for novel drugs to either standalone or to partner artemisinin for treatment of malaria. Traditionally, plants have, over the years, been a good source of antimalarial drugs. Efficacy and safety of such plants need to be scientifically authenticated. <jats:italic>Aims, Materials<\/jats:italic>, <jats:italic>and Method<\/jats:italic>. This study investigated the <jats:italic>in vitro<\/jats:italic> antiplasmodial activity, cytotoxicity, and genotoxicity of aqueous extracts of <jats:italic>Acanthospermum hispidum<\/jats:italic> DC, <jats:italic>Alstonia<\/jats:italic> boone (De Wild), <jats:italic>Cocos nucifera L, Cymbopogon citratus<\/jats:italic> (DC.) Stapf, <jats:italic>Morinda lucida<\/jats:italic> Benth, <jats:italic>Psidium guajava<\/jats:italic>, <jats:italic>Phyllanthus niruri<\/jats:italic> L, and <jats:italic>Senna siamea<\/jats:italic> Lam. <jats:italic>Results<\/jats:italic>. Five out of the eight plants, <jats:italic>A. boonei<\/jats:italic> stem bark, <jats:italic>S; siamea<\/jats:italic> Lam root, <jats:italic>M. lucida Benth<\/jats:italic> leaves, <jats:italic>P. niruri,<\/jats:italic> and <jats:italic>A. hispidum<\/jats:italic> DC whole plants, showed varying degrees of antiplasmodial activity against the asexual stage of the parasite. The most active extract against chloroquine\u2010sensitive (3D7) and chloroquine\u2010resistant (Dd2) <jats:italic>P. falciparum<\/jats:italic> strains is the <jats:italic>A. hispidum<\/jats:italic> extract which yielded a mean inhibitory concentration at 50% (IC<jats:sub>50<\/jats:sub>) of 3.66\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml and 3.71\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml for 3D7 and Dd2, respectively. This was followed by <jats:italic>S. siamea<\/jats:italic> Lam with 3.95\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml for 3D7 and 4.47\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml for Dd2. The IC<jats:sub>50<\/jats:sub> values of the <jats:italic>A. boonei<\/jats:italic> extract against 3D7 and Dd2 <jats:italic>P. falciparum<\/jats:italic> parasites were 5.13\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml and 3.62\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml, respectively. For the <jats:italic>M. lucida Benth<\/jats:italic> extract, the least IC<jats:sub>50<\/jats:sub> value was 6.46\u2009<jats:italic>\u00b5<\/jats:italic>g\/ml. All five extracts exhibited dose\u2010dependent antiplasmodial activity. Assessment of the genotoxic effects the <jats:italic>A. hispidum<\/jats:italic> extract by the comet assay revealed substantial damage to <jats:italic>P. falciparum<\/jats:italic> DNA. <jats:italic>Conclusion<\/jats:italic>. This study demonstrates that the crude extract of <jats:italic>A. hispidum<\/jats:italic> DC, one of the plants used traditionally to treat malaria, inhibits the growth of P. falciparum <jats:italic>in vitro<\/jats:italic> and could be a potential source of antimalarial drug. The report has highlighted genotoxic and cytotoxic effects of the selected plant extracts on human leukocytes as well.<\/jats:p>","DOI":"10.1155\/2020\/1582724","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T01:27:44Z","timestamp":1600910864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antiplasmodial and Genotoxic Study of Selected Ghanaian Medicinal Plants"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-996X","authenticated-orcid":false,"given":"Selorme","family":"Adukpo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Elewosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-2422","authenticated-orcid":false,"given":"Richard Harry","family":"Asmah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Nyarko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Kwaku","family":"Ekpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic Adotei","family":"Edoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-7514","authenticated-orcid":false,"given":"Michael Fokua","family":"Ofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"World Malaria Report 2019. 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