{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:48:41Z","timestamp":1776844121847,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":119,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["18A320005"],"award-info":[{"award-number":["18A320005"]}]},{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["19A360032"],"award-info":[{"award-number":["19A360032"]}]},{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["182102310182"],"award-info":[{"award-number":["182102310182"]}]},{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["18A320005"],"award-info":[{"award-number":["18A320005"]}]},{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["19A360032"],"award-info":[{"award-number":["19A360032"]}]},{"name":"Scientific Research Projects of Higher Education Institutions in Henan Province","award":["182102310182"],"award-info":[{"award-number":["182102310182"]}]},{"name":"Scientific and Technological Research Projects of Henan Province","award":["18A320005"],"award-info":[{"award-number":["18A320005"]}]},{"name":"Scientific and Technological Research Projects of Henan Province","award":["19A360032"],"award-info":[{"award-number":["19A360032"]}]},{"name":"Scientific and Technological Research Projects of Henan Province","award":["182102310182"],"award-info":[{"award-number":["182102310182"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. With the development of biological technology, biomarkers for the prevention and diagnosis of acute coronary syndrome (ACS) have become increasingly evident. However, the study of novel circular RNAs (circRNAs) in ACS is still in progress. This study aimed to investigate whether the regulation of circRNA\u2010miRNA networks is involved in ACS pathogenesis. <jats:italic>Methods<\/jats:italic>. We used microarray analysis to detect significantly expressed circRNAs and miRNAs in the peripheral blood of patients in the control group (CG) and ACS groups, including an unstable angina pectoris (UAP) group and an acute myocardial infarction (AMI) group. A circRNA\u2010miRNA interaction network analysis was carried out with open\u2010source bioinformatics. The gene ontology (GO), pathway, and disease enrichment analyses for differentially expressed circRNAs were further analysed with hierarchical clustering. <jats:italic>Results<\/jats:italic>. A total of 266 circRNAs (121 upregulated and 145 downregulated, <jats:italic>P<\/jats:italic> &lt; 0.05, fold change FC\u2009\u22652) and 3 miRNAs (1 upregulated and 2 downregulated, <jats:italic>P<\/jats:italic> &lt; 0.05, FC\u2009\u2265\u20091.2) were differentially expressed in the ACS groups compared with those in the CG. In addition, among these expressed circRNAs and miRNAs, a single circRNA could bind to more than 1\u2013100 miRNAs, and vice versa. Next, an AMI\u2010UAP network, an AMI\u2010CG network, a UAP\u2010CG network, and an AMI\u2010CG\u2010UAP network were constructed. The top 30 enriched GO terms among the three groups were emphasized as differentially expressed. Disease enrichment analysis showed that these differentially expressed circRNAs are involved in the pathogenesis of cardiovascular diseases. KEGG pathway analysis was performed to identify pathways associated with circRNAs targeting mRNAs. <jats:italic>Conclusion<\/jats:italic>. CircRNAs are closely related to the pathological process of ACS via a mechanism that may be related to the up\u2010 or down\u2010regulation of circRNAs and miRNAs and circRNA\u2010miRNA coexpression. The metabolic pathways, signalling pathways, and diseases affected by these circRNAs can be predicted by enrichment analysis.<\/jats:p>","DOI":"10.1155\/2020\/1584052","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T23:32:20Z","timestamp":1588203140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of the Molecular Mechanism of Acute Coronary Syndrome Based on circRNA\u2010miRNA Network Regulation"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-9985","authenticated-orcid":false,"given":"Fei","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YaMing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-0646","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-7374","authenticated-orcid":false,"given":"Guoan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.034"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0185-2"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.035667.112"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.017"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2959"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03016-5"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1135-7"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101746"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.08.012"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0218-x"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2015"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.03.002"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-103758"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105387"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw563"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.9905"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy856"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e318256f1e0"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000095"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3975"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1242"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0376-2491.2018.11.012"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8048691"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4441"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27285"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.042474"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6055"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2047"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.030"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)33079-4"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(19)32008-2"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902507r"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.02.017"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.31"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2017.1279788"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.010"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11777-7"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/1584052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/1584052.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/1584052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:07:58Z","timestamp":1723014478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/1584052"}},"subtitle":[],"editor":[{"given":"Ghee T.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/1584052"],"URL":"https:\/\/doi.org\/10.1155\/2020\/1584052","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1584052"}}