{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:07:19Z","timestamp":1787591239195,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dalian Traditional Chinese Medicine Related Scientific Research Program","award":["18Z1007"],"award-info":[{"award-number":["18Z1007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID\u201019, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in <jats:italic>Nigella sativa<\/jats:italic> seeds. It has a variety of beneficial properties including anti\u2010inflammatory and antioxidative activities. Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB\/c mice. Eight\u2010week\u2010old male BALB\/c mice were divided into four groups: control, TQ, cecal ligation and puncture (CLP), and TQ+CLP. CLP was performed after 2 weeks of TQ gavage. After 48\u2009h, we measured the histopathological alterations in the kidney tissue and the serum levels of creatinine (CRE) and blood urea nitrogen (BUN). We also evaluated pyroptosis (NLRP3, caspase\u20101), apoptosis (caspase\u20103, caspase\u20108), proinflammatory (TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and IL\u20106)\u2010related protein and gene expression levels. Our results demonstrated that TQ inhibited CLP\u2010induced increased serum CRE and BUN levels. It also significantly inhibited the high levels of NLRP3, caspase\u20101, caspase\u20103, caspase\u20108, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and IL\u20106 induced by CLP. Furthermore, NF\u2010<jats:italic>\u03ba<\/jats:italic>B protein level was significantly decreased in the TQ+CLP group than in the CLP group. Together, our results indicate that TQ may be a potential therapeutic agent for sepsis\u2010induced AKI.<\/jats:p>","DOI":"10.1155\/2020\/1594726","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T23:30:41Z","timestamp":1592350241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB\/c Mice"],"prefix":"10.1155","volume":"2020","author":[{"given":"Li-Peng","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-8898","authenticated-orcid":false,"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-465X","authenticated-orcid":false,"given":"Xiao-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.02.034"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032401"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.01.002"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000052"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.03.019"},{"key":"e_1_2_10_8_2","first-page":"741","article-title":"The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A Review","volume":"20","author":"Ragheb A.","year":"2009","journal-title":"Saudi Journal of Kidney Diseases and Transplantation"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.197475"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31827a2be1"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.007"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.06.038"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.214"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-020-02831-2"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117695245"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.002"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2012.06.006"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.05.001"},{"key":"e_1_2_10_19_2","first-page":"2677","article-title":"Role of Ankaferd on bacterial translocation and inflammatory response in an experimental rat model of intestinal obstruction","volume":"7","author":"Sen V.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_10_20_2","first-page":"1924","article-title":"Pachymic acid ameliorates sepsis-induced acute kidney injury by suppressing inflammation and activating the Nrf2\/HO-1 pathway in rats","volume":"21","author":"Cai Z. 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