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Seeds of Irvingia gabonensis have been reported to possess both nutritional and medicinal values which include antidiabetic, weight losing, antihyperlipidemic, and antioxidative effects. Protective effects of Irvingia gabonensis ethanol seed extract (IGESE) was investigated in doxorubicin (DOX)-mediated cardiotoxicity induced with single intraperitoneal injection of 15\u2009mg\/kg of DOX following the oral pretreatments of Wistar rats with 100-400\u2009mg\/kg\/day of IGESE for 10 days, using serum cardiac enzyme markers (cardiac troponin I (cTI) and lactate dehydrogenase (LDH)), cardiac tissue oxidative stress markers (catalase (CAT), malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH)), and cardiac histopathology endpoints. In addition, both qualitative and quantitative analyses to determine IGESE\u2019s secondary metabolites profile and its in vitro antioxidant activities were also conducted. Results revealed that serum cTnI and LDH were significantly elevated by the DOX treatment. Similarly, activities of tissue SOD, CAT, GST, and GSH levels were profoundly reduced, while GPx activity and MDA levels were profoundly increased by DOX treatment. These biochemical changes were associated with microthrombi formation in the DOX-treated cardiac tissues on histological examination. However, oral pretreatments with 100-400\u2009mg\/kg\/day of IGESE dissolved in 5% DMSO in distilled water significantly attenuated increases in the serum cTnI and LDH, prevented significant alterations in the serum lipid profile and the tissue activities and levels of oxidative stress markers while improving cardiovascular disease risk indices and DOX-induced histopathological lesions. The in vitro antioxidant studies showed IGESE to have good antioxidant profile and contained 56 major secondary metabolites prominent among which are \u03b3-sitosterol, Phytol, neophytadiene, stigmasterol, vitamin E, hexadecanoic acid and its ethyl ester, Phytyl palmitate, campesterol, lupeol, and squalene. Overall, both the in vitro and in vivo findings indicate that IGESE may be a promising prophylactic cardioprotective agent against DOX-induced cardiotoxicity, at least in part mediated via IGESE\u2019s antioxidant and free radical scavenging and antithrombotic mechanisms.<\/jats:p>","DOI":"10.1155\/2020\/1602816","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T05:54:47Z","timestamp":1603518887000},"page":"1-14","source":"Crossref","is-referenced-by-count":8,"title":["Irvingia gabonensis Seed Extract: An Effective Attenuator of Doxorubicin-Mediated Cardiotoxicity in Wistar Rats"],"prefix":"10.1155","volume":"2020","author":[{"given":"Olufunke","family":"Olorundare","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-6282","authenticated-orcid":true,"given":"Adejuwon","family":"Adeneye","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinyele","family":"Akinsola","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Kolo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Clinical, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olalekan","family":"Agede","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday","family":"Soyemi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Mgbehoma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"Okoye","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Medicine, Faculty of Dentistry, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, 1675 Observatory Drive, University of Wisconsin, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-077X","authenticated-orcid":true,"given":"Hasan","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Wisconsin, Madison, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312103"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.04.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2012.01567.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2921"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142588"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-337"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000381"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1159\/000455823"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.0482"},{"key":"10","volume-title":"Doxorubicin in: Martindale: The Complete Drug Reference","author":"A. 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