{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:21:24Z","timestamp":1780474884676,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":242,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2018Y0067"],"award-info":[{"award-number":["2018Y0067"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To investigate the expression of glucose transporter 3 (GLUT3) and hypoxia\u2010inducible factor\u20101<jats:italic>\u03b1<\/jats:italic> protein (HIF\u20101<jats:italic>\u03b1<\/jats:italic>) in meningiomas and analyze the correlation between GLUT3 and HIF\u20101<jats:italic>\u03b1<\/jats:italic> expression with the pathological grade of peritumoral brain edema (PTBE) of meningiomas. <jats:italic>Methods<\/jats:italic>. In this cross\u2010sectional study, we analyzed meningioma specimens from 160 patients collected from January 1, 2014, to December 1, 2017, by dividing them into a low\u2010grade (WHO I) or high\u2010grade (WHO II and WHO III) group. Immunohistochemical analyses were used to detect the expression level of GLUT3 and HIF\u20101<jats:italic>\u03b1<\/jats:italic> in the tumor specimens. <jats:italic>Results<\/jats:italic>. The proportion of GLUT3\u2010positive staining in tumors sized &lt;4\u2009cm, 4\u20136\u2009cm, and&gt;6\u2009cm was 35.9% (37\/103), 63.6% (28\/44), and 53.8% (7\/13), respectively (<jats:italic>P<\/jats:italic> = 0.007). The proportion of HIF\u20101<jats:italic>\u03b1<\/jats:italic>\u2010positive staining in tumors sized &lt;4\u2009cm, 4\u20136\u2009cm, and &gt;6\u2009cm was 41.7% (43\/103), 68.2% (30\/44), and 38.5% (5\/13), respectively (<jats:italic>P<\/jats:italic> = 0.010). The proportion of GLUT3\u2010positive staining in the high\u2010grade group and low\u2010grade group was 70.8% (34\/48) and 33.9% (38\/112), respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). The proportion of HIF\u20101<jats:italic>\u03b1<\/jats:italic>\u2010positive staining in the high\u2010grade group and low\u2010grade group was 62.5% (30\/48) and 42.9% (48\/112), respectively (<jats:italic>P<\/jats:italic> = 0.023). GLUT3\u2010positive expression in meningioma PTBE grades 0, I, II, and III was 20.3% (13\/64), 41.2% (14\/34), 63.6% (21\/33), and 82.8% (24\/29), respectively (Bonferroni\u2010corrected, <jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>\u03b1<\/jats:italic>\/6 = 0.008). HIF\u20101<jats:italic>\u03b1<\/jats:italic>\u2010positive expression in meningioma PTBE grades 0, I, II, and III was 34.4% (22\/64), 47.1% (16\/34), 54.5% (18\/33), and 75.9% (22\/29), respectively (Bonferroni\u2010corrected, <jats:italic>P<\/jats:italic> = 0.003, <jats:italic>\u03b1<\/jats:italic>\/6 = 0.008). Spearman\u2019s correlation analysis revealed a correlation between the expression of GLUT3 and HIF\u20101<jats:italic>\u03b1<\/jats:italic> in meningiomas (<jats:italic>r<\/jats:italic> = 0.463, <jats:italic>P<\/jats:italic> &lt; 0.001). Multivariate analysis revealed that GLUT3\u2010positive expression, HIF\u20101<jats:italic>\u03b1<\/jats:italic>\u2010positive expression, and high pathological grade were associated with the development of PTBE (<jats:italic>P<\/jats:italic> &lt; 0.05). <jats:italic>Conclusions<\/jats:italic>. GLUT3 and HIF\u20101<jats:italic>\u03b1<\/jats:italic> expression in meningiomas was closely related to the tumor size, pathological grade, and PTBE. This study is the first to report a unique map\u2010like multifocal GLUT3 staining pattern in meningiomas.<\/jats:p>","DOI":"10.1155\/2020\/1682352","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T23:30:29Z","timestamp":1598830229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression of GLUT3 and HIF\u20101<i>\u03b1<\/i> in Meningiomas of Various Grades Correlated with Peritumoral Brain 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