{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:57:54Z","timestamp":1790693874426,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["SGKJ-201912"],"award-info":[{"award-number":["SGKJ-201912"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["2018YQ43"],"award-info":[{"award-number":["2018YQ43"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["18SG39"],"award-info":[{"award-number":["18SG39"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973773"],"award-info":[{"award-number":["81973773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874436"],"award-info":[{"award-number":["81874436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774240"],"award-info":[{"award-number":["81774240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673935"],"award-info":[{"award-number":["81673935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673938"],"award-info":[{"award-number":["81673938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673767"],"award-info":[{"award-number":["81673767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Helping B cells and antibody responses is a major function of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper cells. Follicular helper T (Tfh) cells are identified as a subset of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of CXCR5, PD\u20101, IL\u201021, and other characteristic markers. Accumulating evidence has demonstrated that the dysregulation of Tfh cells is involved in infectious, inflammatory, and autoimmune diseases, including lymphocytic choriomeningitis virus (LCMV) infection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgG4\u2010related disease (IgG4\u2010RD), Sj\u00f6gren syndrome (SS), and type 1 diabetes (T1D). Activation of subset\u2010specific transcription factors is the essential step for Tfh cell differentiation. The differentiation of Tfh cells is regulated by a complicated network of transcription factors, including positive factors (Bcl6, ATF\u20103, Batf, IRF4, c\u2010Maf, and so on) and negative factors (Blimp\u20101, STAT5, IRF8, Bach2, and so on). The current knowledge underlying the molecular mechanisms of Tfh cell differentiation at the transcriptional level is summarized in this paper, which will provide many perspectives to explore the pathogenesis and treatment of the relevant immune diseases.\n                  <\/jats:p>","DOI":"10.1155\/2020\/1826587","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T19:31:21Z","timestamp":1595273481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors"],"prefix":"10.1155","volume":"2020","author":[{"given":"Long-Shan","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-3860","authenticated-orcid":false,"given":"Xue-Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6523-0526","authenticated-orcid":false,"given":"Xiao-Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-143X","authenticated-orcid":false,"given":"Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-9810","authenticated-orcid":false,"given":"Yue-Qiu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00606"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175870"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103246"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12910"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00480"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3229"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176676"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.07.002"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101393"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.023"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6508"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129018"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40556"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.914868"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818164116"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800050"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.001"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.001"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00701"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000170"},{"key":"e_1_2_16_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212652"},{"key":"e_1_2_16_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01226"},{"key":"e_1_2_16_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170457"},{"key":"e_1_2_16_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111174"},{"key":"e_1_2_16_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324046"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.034"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07853-z"},{"key":"e_1_2_16_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900581"},{"key":"e_1_2_16_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3226"},{"key":"e_1_2_16_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.006"},{"key":"e_1_2_16_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.08.008"},{"key":"e_1_2_16_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801626"},{"key":"e_1_2_16_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801400"},{"key":"e_1_2_16_35_2","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0115"},{"key":"e_1_2_16_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701000"},{"key":"e_1_2_16_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606646113"},{"key":"e_1_2_16_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.013"},{"key":"e_1_2_16_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747034"},{"key":"e_1_2_16_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.004"},{"key":"e_1_2_16_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500201"},{"key":"e_1_2_16_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507312112"},{"key":"e_1_2_16_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203032"},{"key":"e_1_2_16_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190832"},{"key":"e_1_2_16_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2912"},{"key":"e_1_2_16_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-652636"},{"key":"e_1_2_16_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.038"},{"key":"e_1_2_16_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705364114"},{"key":"e_1_2_16_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1837"},{"key":"e_1_2_16_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091548"},{"key":"e_1_2_16_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2037"},{"key":"e_1_2_16_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8997"},{"key":"e_1_2_16_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11530"},{"key":"e_1_2_16_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.009"},{"key":"e_1_2_16_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809077106"},{"key":"e_1_2_16_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-392985"},{"key":"e_1_2_16_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2947"},{"key":"e_1_2_16_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700106"},{"key":"e_1_2_16_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049567"},{"key":"e_1_2_16_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10285"},{"key":"e_1_2_16_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0227-z"},{"key":"e_1_2_16_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801196115"},{"key":"e_1_2_16_63_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800193"},{"key":"e_1_2_16_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.047"},{"key":"e_1_2_16_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2017.1284821"},{"key":"e_1_2_16_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.017"},{"key":"e_1_2_16_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2890"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/1826587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/1826587.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/1826587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:16:21Z","timestamp":1762092981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/1826587"}},"subtitle":[],"editor":[{"given":"Margarete D.","family":"Bagatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/1826587"],"URL":"https:\/\/doi.org\/10.1155\/2020\/1826587","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1826587"}}