{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:53:11Z","timestamp":1790304791441,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970237"],"award-info":[{"award-number":["81970237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Previous studies showed that fibrinogen\u2010to\u2010albumin ratio (FAR) regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). In this study, we sought to evaluate the relationship between FAR and severity of CAD, long\u2010term prognosis in non\u2010ST elevation acute coronary syndrome (NSTE\u2010ACS) patients firstly implanted with drug\u2010eluting stent (DES). A total of 1138 consecutive NSTE\u2010ACS patients firstly implanted with DES from January 2017 to December 2018 were recruited in this study. Patients were divided into tertiles according to FAR levels (Group 1: \u22648.715%; Group 2: 8.715%~10.481%; and Group 3: &gt;10.481%). The severity of CAD was evaluated using the Gensini Score (GS). The endpoints were major adverse cardiovascular events (MACE), including all\u2010cause mortality, myocardial reinfarction, and target vessel revascularization (TVR). Positive correlation was detected by Spearman\u2019s rank correlation coefficient analysis between FAR and GS (<jats:italic>r<\/jats:italic> = 0.170, <jats:italic>P<\/jats:italic> &lt; 0.001). On multivariate logistic analysis, FAR was an independent predictor of severe CAD (OR: 1.060; 95% CI: 1.005~1.118; <jats:italic>P<\/jats:italic> &lt; 0.05). Multivariate Cox regression analysis indicated that FAR was an independent prognostic factor for MACE at 30 days, 6 months, and 1 year after DES implantation (HR: 1.095; 95% CI: 1.011~1.186; <jats:italic>P<\/jats:italic> = 0.025. HR: 1.076; 95% CI: 1.009~1.147; <jats:italic>P<\/jats:italic> = 0.026. HR: 1.080; 95% CI: 1.022~1.141; <jats:italic>P<\/jats:italic> = 0.006). Furthermore, adding FAR to the model of established risk factors, the C\u2010statistic increased from 0.706 to 0.720, 0.650 to 0.668, and 0.611 to 0.632, respectively. And the models had incremental prognostic value for MACE, especially for 1\u2010year MACE (NRI: 13.6% improvement, <jats:italic>P<\/jats:italic> = 0.044; IDI: 0.6% improvement, <jats:italic>P<\/jats:italic> = 0.042). In conclusion, FAR was associated independently with the severity of CAD and prognosis, helping to improve risk stratification in NSTE\u2010ACS patients firstly implanted with DES.<\/jats:p>","DOI":"10.1155\/2020\/1860268","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T23:41:11Z","timestamp":1597707671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Relation of Fibrinogen\u2010to\u2010Albumin Ratio to Severity of Coronary Artery Disease and Long\u2010Term Prognosis in Patients with Non\u2010ST Elevation Acute Coronary 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