{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:50:37Z","timestamp":1792101037107,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Acute bronchitis is defined as a sudden inflammation of the bronchial tubes in the lung mainly caused by viral infection. It is characterized by a persistent cough which can be productive or dry. It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk\u2010benefit ratio. <jats:italic>Objective<\/jats:italic>. The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575\u00ae by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. Acetylcysteine (ACC) was chosen as comparator drug (common mono preparations). <jats:italic>Material and Methods<\/jats:italic>. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. <jats:italic>Results<\/jats:italic>. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. At the final visit after seven days of treatment, there was a comparable improvement in both groups for all assessments except dyspnoea and number of cough attacks which showed a higher improvement in the EA 575\u00ae group compared with ACC. Further, cough\u2010associated sleeping disorders improved more in the EA 575\u00ae group. Both, physicians and patients described the efficacy of EA 575\u00ae comparable with acetylcysteine. Observations of the tolerability were comparable for both products. The study results indicate that ivy leaf extract might be an effective alternative to acetylcysteine with respect to the improvement of respiratory function in children and adults at a slightly better evaluation of efficacy.<\/jats:p>","DOI":"10.1155\/2020\/1910656","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T23:44:26Z","timestamp":1588722266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Assessment of the Efficacy and Safety of Ivy Leaf (<i>Hedera helix<\/i>) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-392X","authenticated-orcid":false,"given":"Esther","family":"Kruttschnitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tankred","family":"Wegener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Zahner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Henzen-B\u00fccking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"EMA Assessment report onHedera helixL. folium 2017 European Medicines Agency Committee on Herbal Medicinal Products (HMPC) Amsterdam Netherlands EMA\/HMPC\/325715\/2017."},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp061493"},{"key":"e_1_2_9_3_2","first-page":"1","article-title":"Current estimates from the national health interview survey, 1995","volume":"10","author":"Benson V.","year":"1998","journal-title":"Vital and Health Statistics"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.2.109"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-4924-9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0599-3_8"},{"key":"e_1_2_9_7_2","volume-title":"Allgemeinmedizin","author":"Schrader D.","year":"1993"},{"key":"e_1_2_9_8_2","first-page":"697","article-title":"Spiegel MV. 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