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Acupuncture at Zusanli (ST36), Quchi (LI11), and Tianshu (ST25) is commonly used in septic patients by traditional Chinese physicians. The protective effect of acupuncture at ST36 on the intestinal barrier is associated with Cholinergic Anti\u2010Inflammatory Pathway (CAIP). However, its detailed mechanism and whether acupuncture at LI11 and ST25 have similar effects to ST36 remain unclear. <jats:italic>Aim<\/jats:italic>. To explore the effects of electroacupuncture (EA) at ST36, LI11, and ST25 on septic rats and investigate the role of the spleen in the treatment of EA at ST36. <jats:italic>Methods<\/jats:italic>. A septic rat model caused by cecal ligation and puncture (CLP) and a postsplenectomy (SPX) CLP rat model were established. Rats were divided into nine groups depending on different treatments. Serum levels of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u201010, D\u2010lactic acidosis (D\u2010LA), double amine oxidase (DAO), and T\u2010lymphocyte subgroup level in intestinal lymph nodes were compared. <jats:italic>Results<\/jats:italic>. EA could not improve the 2\u2010day survival of CLP rats. For CLP rats, EA at ST36 and LI11 significantly decreased the levels of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u201010, DAO, and D\u2010LA in serum and normalized intestinal T\u2010cell immunity. For SPX CLP rats, EA at ST36 failed to reduce serum concentrations of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u201010, and D\u2010LA but increased the values of CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>\/CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> cells and Treg\/Th17 cells. <jats:italic>Conclusions<\/jats:italic>. EA at ST36 and LI11, respectively, could alleviate inflammation reaction, protect the intestinal barrier, and maintain intestinal T\u2010cell function in septic rats. Spleen participated in the protective effect of EA at ST36 in sepsis.<\/jats:p>","DOI":"10.1155\/2020\/1914031","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:25:37Z","timestamp":1602145537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen"],"prefix":"10.1155","volume":"2020","author":[{"given":"Dong-ping","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng-biao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-lian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong-dong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-na","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-tao","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-1257","authenticated-orcid":false,"given":"Fang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781oc"},{"key":"e_1_2_12_2_2","article-title":"Inpatient care for septicemia or sepsis: a challenge for patients and hospitals","volume":"62","author":"Hall M. 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