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Osteoclasts play an important role in bone destruction and osteoporosis, and they are derived from monocyte\/macrophages in response to macrophage colony\u2010stimulating factor (M\u2010CSF) and receptor activator of nuclear factor <jats:italic>\u03ba<\/jats:italic>B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) ligand (RANKL). <jats:italic>Amaranthus mangostanus<\/jats:italic> L. (AM) is a plant with powerful antioxidant and other biological activities including anti\u2010inflammatory, antidiabetic, and antihyperlipidemic effects. However, its effects on bone health are unknown. In this study, we explored whether AM could affect RANK\u2010mediated osteoclastogenesis. AM significantly suppressed RANKL\u2010induced osteoclast differentiation and expression of osteoclast\u2010specific genes, TRAP, cathepsin K, NF\u2010activated T\u2010cells (NFATc1), and Dc\u2010stamp in RAW 264.7 cells. Moreover, AM significantly inhibited extracellular signal\u2010regulated kinase (ERK), Akt, and NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathways in RAW 264.7 cells. In addition, AM preserved ovariectomy\u2010induced bone loss in mice. Taken together, our results suggest that AM might be a potential candidate for the treatment of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1155\/2020\/1927017","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T23:31:36Z","timestamp":1581118296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Amaranthus mangostanus<\/i> Inhibits the Differentiation of Osteoclasts and Prevents Ovariectomy\u2010Induced Bone Loss"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yeon-Hui","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeng Jeon","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ae Sin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang 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