{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:02:43Z","timestamp":1789585363959,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":152,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007713","name":"Bahauddin Zakariya University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The objective of this study was to authenticate the ethnobotanical claims of the <jats:italic>Nepeta ruderalis<\/jats:italic> Buch.\u2010Ham. (<jats:italic>N. ruderalis<\/jats:italic>) extract in the traditional system of medicine. Crude extract was prepared via a simple maceration process. DPPH free radical scavenging and carrageenan\u2010induced rat paw edema models were used to monitor antioxidant and anti\u2010inflammatory responses of the <jats:italic>N. ruderalis<\/jats:italic> extract. Furthermore, it was tested for antiplatelet aggregation, cardioprotective, and calcium channel antagonistic activities via standard documented protocols. The <jats:italic>N. ruderalis<\/jats:italic> extract exhibited 80.82% antioxidant activity (IC<jats:sub>50<\/jats:sub> = 207.51 \u00b1 4.36\u2009<jats:italic>\u03bc<\/jats:italic>g) while the anti\u2010inflammatory response was significant (<jats:italic>p<\/jats:italic> &lt; 0.05 to <jats:italic>p<\/jats:italic> &lt; 0.01) at 50\u2009mg\/kg (45.58%) and 100\u2009mg\/kg (60.90%) doses. Moreover, it was found to inhibit platelet aggregation (IC<jats:sub>50<\/jats:sub> = 1.06 and 0.91\u2009mg\/mL) and, in addition, to increase the force of contraction at the concentration of 3.0\u201010\u2009mg\/mL with a decrease in the heart rate on isolated paired atria (EC<jats:sub>50<\/jats:sub> = 11.78\u2009mg\/mL). Relaxant activity was observed on the isolated rabbit jejunum (EC<jats:sub>50<\/jats:sub> = 0.96\u2009mg\/mL) and trachea (EC<jats:sub>50<\/jats:sub> = 0.89\u2009mg\/mL). However, in a cumulative way, an 80\u2010millimolar potassium\u2010induced contraction was evaluated (EC<jats:sub>50<\/jats:sub> = 1.31\u2009mg\/mL). The <jats:italic>N. ruderalis<\/jats:italic> extract exhibited antioxidant, anti\u2010inflammatory, platelet aggregating, cardiotonic, and calcium channel antagonistic activities, therefore proving scientifically its effectiveness in the traditional system of medicine.<\/jats:p>","DOI":"10.1155\/2020\/2096947","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T23:30:48Z","timestamp":1591054248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiplatelet Aggregation, Cardiotonic, Anti\u2010Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of <i>Nepeta ruderalis<\/i> Buch"],"prefix":"10.1155","volume":"2020","author":[{"given":"Ambreen","family":"Aleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Hussain","family":"Janbaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-8574","authenticated-orcid":false,"given":"Imran","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muqeet","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumbal","family":"Bibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-9416","authenticated-orcid":false,"given":"Muhammad Hassham Hassan Bin","family":"Asad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"Indian Materia Medica","author":"Nadkarni K. 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