{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:03:08Z","timestamp":1782288188483,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020,4,25]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Transforming growth factor-beta (TGF-<jats:italic>\u03b2<\/jats:italic>) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD). In this study, we aim to assess the levels of TGF-<jats:italic>\u03b2<\/jats:italic> and HGF and other inflammatory markers in patients with IBD and correlate them with the disease activity. <jats:italic>Study Design<\/jats:italic>. A cross-sectional study involving 100 patients with ulcerative colitis (UC) and 100 patients with Crohn\u2019s disease (CD) and 50 control subjects. TGF-<jats:italic>\u03b2<\/jats:italic> and HGF levels were measured and correlated with disease activity. <jats:italic>Results and Conclusion<\/jats:italic>. Serum levels of TGF-<jats:italic>\u03b2<\/jats:italic> and HGF were significantly higher in IBD patients compared with the control group. In the UC group, the levels of HGF and TGF-<jats:italic>\u03b2<\/jats:italic> were significantly higher than in the CD group. Levels of TGF-<jats:italic>\u03b2<\/jats:italic> and HGF correlate with the activity of IBD.<\/jats:p>","DOI":"10.1155\/2020\/2104314","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T23:30:51Z","timestamp":1587857451000},"page":"1-5","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-7182","authenticated-orcid":true,"given":"Rania","family":"Naguib","sequence":"first","affiliation":[{"name":"Clinical Science Department, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia"},{"name":"Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa Mohamed","family":"El-Shikh","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5604\/17322693.1086361","volume":"68","year":"2014","journal-title":"A Pilot Study. 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