{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:07Z","timestamp":1753884667743,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin\u2010converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single\u2010tablet combination in patients with hypertension, a heart rate higher than 70 beats\/min, and type 2 diabetes mellitus (T2DM). This study was conducted in Turkey as a prospective, noninterventional, observational study. At 22 clinical sites, the data of 200 patients with hypertension were used for efficacy analysis; however, 262 patients received at least one dose of trandolapril\/verapamil fixed\u2010dose combination at two dose strengths. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, PR interval, glycated haemoglobin (HbA1c), and albumin\/creatinine ratios were recorded during 8 weeks of treatment. With treatment, the mean (\u00b1SD) SBP that was recorded as 162.8 (\u00b114.642)\u2009mm Hg at baseline was reduced to 131.7 \u00b1 11.1\u2009mm Hg at week 8 (<jats:italic>p<\/jats:italic> &lt; 0.05). Similarly, the mean DBP was reduced from 93.76 \u00b1 9.16\u2009mm Hg to 77.6 \u00b1 7.6\u2009mm Hg (<jats:italic>p<\/jats:italic> &lt; 0.001). Following 8 weeks of treatment, SBP and DBP values were reduced below 140\u2009mm Hg and 90\u2009mm Hg in most patients (81.5%), respectively. The mean heart rate as evaluated using electrocardiography measurements was reduced to 78.25 beats\/min at week 8 as compared with baseline during trandolapril\/verapamil single\u2010pill combination treatment (<jats:italic>p<\/jats:italic> &lt; 0.001). Treatment with trandolapril and verapamil was well tolerated over 8 weeks with no unexpected safety signals. In conclusion, the single\u2010pill combination of trandolapril and verapamil was considered effective in reducing and controlling blood pressure in patients with hypertension and T2DM. There was a significant improvement in HbA1c and ACR levels in a smaller subgroup of the patient cohort. The trandolapril\/verapamil combination was evaluated as being safe and well\u2010tolerated following a treatment period of 8 weeks. This trial was registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02298556\">NCT02298556<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2020\/2123601","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T23:30:57Z","timestamp":1599521457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single\u2010Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-1402","authenticated-orcid":false,"given":"Enver","family":"Atalar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Eskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haci Bayram","family":"Tugtekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpaslan","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Kanyilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Kirbiyik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Gokhan","family":"Ozyildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.5494\/wjh.v6.i1.53"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16456-8"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05012-0"},{"key":"e_1_2_9_5_2","first-page":"2159","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"43","author":"Mancia G.","year":"2013","journal-title":"European Heart Journal"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2000.055"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328333146d"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.09.107"},{"key":"e_1_2_9_9_2","article-title":"Cardiac remodeling\u2013concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling","volume":"3","author":"Cohn J. 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