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However, the mechanisms underlying PE remained largely unclear. The present study identified 1716 high expressions of gene and 2705 low expressions of gene using GSE60438 database, and identified 7087 hypermethylated and 15120 hypomethylated genes in preeclampsia using GSE100197. Finally, 536 upregulated genes with hypomethylation and 322 downregulated genes with hypermethylation were for the first time revealed in PE. Gene Ontology (GO) analysis revealed that these genes were associated with peptidyl-tyrosine phosphorylation, skeletal system development, leukocyte migration, transcription regulation, T cell receptor and IFN-\u03b3-involved pathways, innate immune response, signal transduction, cell adhesion, angiogenesis, and hemopoiesis. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis demonstrated that aberrantly methylated differentially expressed genes were involved in regulating adherens junction, pluripotency of stem cell regulation, immune processing, T cell receptor and NF-\u03baB pathways, HTLV-I and HSV infections, leishmaniasis, and NK-induced cytotoxicity. Protein-protein interaction (PPI) network analysis identified several hub networks and key genes, including MAPK8, CCNF, CDC23, ABL1, NF1, UBE2E3, CD44, and PIK3R1. We hope these findings will draw more attention to these hub genes in future PE studies.<\/jats:p>","DOI":"10.1155\/2020\/2139270","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T22:50:13Z","timestamp":1604357413000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia"],"prefix":"10.1155","volume":"2020","author":[{"given":"Wenyi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuorong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixia","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kongjiang Hospital, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Life Science, Sichuan Agricultural University, Sichuan 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-4142","authenticated-orcid":true,"given":"Zhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-207X","authenticated-orcid":true,"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v29i1.4"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00006205-198901000-00012","article-title":"Factors associated with pregnancy-induced hypertension","volume":"14","author":"M. 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