{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:05:09Z","timestamp":1790798709168,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation Brugmann"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To assess neurocognitive function (NCF), psychosocial outcome, health\u2010related quality of life (HRQoL), and long\u2010term effects of immune\u2010related adverse events (irAE) on metastatic melanoma survivors treated with ipilimumab (IPI).\n                    <jats:italic>Methods<\/jats:italic>\n                    . Melanoma survivors were identified within two study populations (\n                    <jats:italic>N<\/jats:italic>\n                    = 104), at a single\u2010center university hospital, and defined as patients who were disease\u2010free for at least 2 years after initiating IPI. Data were collected using 4 patient\u2010reported outcome measures, computerized NCF testing, and a semistructured interview at the start and 1\u2010year follow\u2010up.\n                    <jats:italic>Results<\/jats:italic>\n                    . Out of 18 eligible survivors, 17 were recruited (5F\/12M); median age is 57 years (range 33\u201086); and median time since initiating IPI was 5.6 years (range 2.1\u20109.3). The clinical interview revealed that survivors suffered from cancer\u2010related emotional distress such as fear of recurrence (\n                    <jats:italic>N<\/jats:italic>\n                    = 8), existential problems (\n                    <jats:italic>N<\/jats:italic>\n                    = 2), survivor guilt (\n                    <jats:italic>N<\/jats:italic>\n                    = 2), and posttraumatic stress disorder (\n                    <jats:italic>N<\/jats:italic>\n                    = 6). The mean EORTC QLQ\u2010C30 Global Score was not significantly different from the European mean of the healthy population. Nine survivors reported anxiety and\/or depression (Hospitalization Depression Scale) during the survey. Seven survivors (41%) reported fatigue (Fatigue Severity Scale). Seven patients (41%) had impairment in NCF; only three out of seven survivors had impairment in subjective cognition (Cognitive Failure Questionnaire). Anxiety, depression, fatigue, and neurocognitive symptoms remained stable at the 1\u2010year follow\u2010up. All cases of skin toxicity (\n                    <jats:italic>N<\/jats:italic>\n                    = 8), hepatitis (\n                    <jats:italic>N<\/jats:italic>\n                    = 1), colitis (\n                    <jats:italic>N<\/jats:italic>\n                    = 3), and sarcoidosis (\n                    <jats:italic>N<\/jats:italic>\n                    = 1) resolved without impact on HRQoL. Three survivors experienced hypophysitis; all suffered from persistent fatigue and cognitive complaints 5 years after onset. One survivor who experienced a Guillain\u2010Barr\u00e9\u2010like syndrome suffered from persisting depression, fatigue, and impairment in NCF.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . A majority of melanoma survivors treated with IPI continue to suffer from emotional distress and impairment in NCF. Timely detection in order to offer tailored care is imperative, with special attention for survivors with a history of neuroendocrine or neurological irAE. The trial is registered with B.U.N. 143201421920.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2192480","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T19:32:44Z","timestamp":1595359964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Neurocognitive Function, Psychosocial Outcome, and Health\u2010Related Quality of Life of the First\u2010Generation Metastatic Melanoma Survivors Treated with Ipilimumab"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-2559","authenticated-orcid":false,"given":"Anne","family":"Rogiers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Lauwyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Schembri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-0430","authenticated-orcid":false,"given":"Gil","family":"Awada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8990-5380","authenticated-orcid":false,"given":"Julia Katharina","family":"Schwarze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7527-7173","authenticated-orcid":false,"given":"Jennifer","family":"De Cremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6713-823X","authenticated-orcid":false,"given":"Peter","family":"Theuns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-8807","authenticated-orcid":false,"given":"Mark","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.","family":"Bernheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-5903","authenticated-orcid":false,"given":"Bart","family":"Neyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5269062"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1801663"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0217"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.06.008"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1901103"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-4025-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049732312448542"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2286-0"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3654"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4290"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(98)00038-9"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.059"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.003"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004382"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-014-0354-0"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2010.01217.x"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_9_20_2","first-page":"1139","article-title":"Fatigue scales used in multiple sclerosis","volume":"158","author":"Debouverie M.","year":"2002","journal-title":"Revista de Neurolog\u00eda"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638281003734458"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1982.tb01421.x"},{"key":"e_1_2_9_23_2","first-page":"37","article-title":"De Cognitive Failure Questionnaire als maat voor subjectief cognitief functioneren","volume":"2","author":"Ponds R. 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