{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:33:26Z","timestamp":1791894806769,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002783","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur, Republique du Cameroun","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2020,1,29]]},"abstract":"<jats:p>Agro pesticides are increasingly used worldwide to increase crop production. However, health hazards resulting from human exposure to these chemicals, especially from agricultural areas of developing countries have been a growing concern. The objective of this study was to evaluate the impact of occupational exposure to agro pesticides on the health of farmers in the Buea subdivision, which is one of the major agrarian areas in Cameroon. The study was transversal and involved 90 participants including 58 farmers using pesticides and a reference population of 32 men not involved in occupational use of agro pesticides. The participants were interviewed on agro pesticide use and their health status. Thereafter, blood samples were collected from the participants and used for the assessment of biochemical markers of the liver (alanine aminotransferase and aspartate aminotransferase) and the kidney (creatinine and uric acid) function. Results revealed that farmers frequently used insecticides, fungicides, and herbicides in their farming activities. Farmers reported several acute health symptoms related to pesticides use with the common ones being skin rash, eye irritation, and face burn. When compared to the reference population, the farmers showed significantly elevated (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) alanine aminotransferase activity. However, other parameters investigated were not affected significantly. These results suggested that farmers were exposed to 3 different classes of agro pesticides, which induced eye and skin affections. Pesticides exposure resulted in alterations of the liver function hence the increased serum alanine aminotransferase activity. Therefore, there is a need to sensitize the farmers on toxicity and liver alteration potential of agro pesticides and the importance of appropriate protective equipment that may minimize exposure.<\/jats:p>","DOI":"10.1155\/2020\/2305764","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T18:30:56Z","timestamp":1580322656000},"page":"1-10","source":"Crossref","is-referenced-by-count":53,"title":["Evaluation of the Effects of Agro Pesticides Use on Liver and Kidney Function in Farmers from Buea, Cameroon"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-7817","authenticated-orcid":true,"given":"Faustin Pascal Tsagu\u00e9","family":"Manfo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, PO Box 63 Buea, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Asukia","family":"Mboe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, PO Box 63 Buea, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard Akono","family":"Nantia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Bamenda, PO Box 39 Bambili, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-1957","authenticated-orcid":true,"given":"Ferdinand","family":"Ngoula","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 188 Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-685X","authenticated-orcid":true,"given":"Ph\u00e9lix Bruno","family":"Telefo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laboratory of Medicinal Plant Biochemistry, Food Science, and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-5569","authenticated-orcid":true,"given":"Paul Fewou","family":"Moundipa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaound\u00e9 I, P.O. 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