{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:36:35Z","timestamp":1790400995338,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2020,10,23]]},"abstract":"<jats:p>Treating infections caused by Pseudomonas aeruginosa is challenging. In addition to its intrinsic ability to develop resistance to multiple classes of antibiotics, it also produces extended-spectrum \u03b2-lactamase (ESBL). Continuous update of the antibiograms is required to cope with the rate of the emergence of antibiotic resistance. This study aimed to determine the antimicrobial susceptibility pattern and to determine the frequency of ESBL production among the P. aeruginosa isolates from patients at two public military hospitals in Khartoum, Sudan. A total of 34 isolates of P. aeruginosa obtained from patients with diabetic septic foot wounds were tested for their antibiotic sensitivity patterns. Resistance occurred most commonly to ceftazidime (35%), followed by ciprofloxacin (20.6%) and piperacillin (14.7%). We found that 17.6% of the P. aeruginosa isolates were ESBL producers, but all of these isolates were sensitive to meropenem. The chi-squared test showed a significant association between the ESBL production and antimicrobial resistance to amikacin, ceftazidime, and piperacillin. Our findings strengthen previous reports in which aminoglycosides (amikacin) and carbapenems (meropenem) were found to be highly effective against P. aeruginosa. Our findings highlight the need for effective surveillance and antibiogram-guided antibiotic prescription.<\/jats:p>","DOI":"10.1155\/2020\/2313504","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T20:36:05Z","timestamp":1603744565000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Extended Spectrum \u03b2-Lactamase-Mediated Resistance and Antibiogram of Pseudomonas aeruginosa Isolates from Patients Attending Two Public Hospitals in Khartoum, Sudan"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-8805","authenticated-orcid":true,"given":"Thweaba Hassan Salih","family":"Omer","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Khartoum, Alqasr Avenue P.O. Box 102, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-8856","authenticated-orcid":true,"given":"Samia Ali Mohammed","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Khartoum, Alqasr Avenue P.O. Box 102, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-2397","authenticated-orcid":true,"given":"Sagad Omer Obeid","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Khartoum, Alqasr Avenue P.O. Box 102, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00203-17"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2015.2096"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0929-693x(10)70921-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3329\/bmrcb.v38i3.14330"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s1067-2516(07)60001-5"},{"issue":"11","key":"6","first-page":"308","article-title":"Microbiological features and risk factors in patients with diabetic foot ulcers","volume":"27","author":"H. Parsa","year":"2015","journal-title":"Wounds: A Compendium of Clinical Research and Practice"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1086\/604713","article-title":"A multinational survey of risk factors for infection with extended-spectrum beta-lactamase- producing enterobacteriaceae in non hospitalized patients","volume":"49","author":"R. Ben-Ami","year":"2009","journal-title":"Clinical Infectious Diseases"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2018.50.1.11"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-4923-1"},{"key":"10","volume-title":"Antimicrobial Resistance: Global Report on Surveillance 2014","author":"World Health Organization","year":"2014"},{"key":"11","volume-title":"Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics","author":"World Health Organization","year":"2017"},{"key":"12","volume-title":"Antibiotic Resistance Threats in the United States","author":"Centers for Disease Control and Prevention","year":"2013"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.71802"},{"key":"15","article-title":"Performance standards for antimicrobial susceptibility testing","volume-title":"Twenty-Fifth Informational Supplement, CLSI Doc. M100eS20","author":"CLSI","year":"2015"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614554919"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4172\/2329-910X.S3-001"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.02.043"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm348"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/s0732-8893(02)00470-4"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2014.68.239-243"},{"issue":"8","key":"22","first-page":"1552","article-title":"ESBL and MBL mediated resistance in Pseudomonas aeruginosa: an emerging threat to clinical therapeutics","volume":"5","author":"P. D. Peshattiwar","year":"2011","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.9734\/bmrj\/2015\/13360"},{"key":"24","article-title":"Extended-spectrum beta-lactamases","author":"L. S. Munoz-Price","year":"2019"},{"issue":"4","key":"25","first-page":"81","article-title":"Occurrence of ESBL and MBL in clinical isolates of Pseudomonas aeruginosa from Lagos, Nigeria","volume":"3","author":"I. Aibinu","year":"2007","journal-title":"Journal of American Science"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00806-09"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01988-06"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2020\/2313504.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2020\/2313504.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2020\/2313504.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T20:36:14Z","timestamp":1603744574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijmicro\/2020\/2313504\/"}},"subtitle":[],"editor":[{"given":"Karl","family":"Drlica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":27,"alternative-id":["2313504","2313504"],"URL":"https:\/\/doi.org\/10.1155\/2020\/2313504","relation":{},"ISSN":["1687-9198","1687-918X"],"issn-type":[{"value":"1687-9198","type":"electronic"},{"value":"1687-918X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,23]]}}}