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Therefore, there are no active disease\u2010modifying drugs currently available for clinical treatment. Several natural compounds have been shown to play a role in inhibiting OA progression. The present study is aimed at investigating the curative effects of acacetin, a natural flavonoid compound, against OA. Our results demonstrated that MMP\u20101, MMP\u20103, and MMP\u201013 were highly expressed in OA specimens. Acacetin inhibited the interleukin\u20101<jats:italic>\u03b2<\/jats:italic>\u2010 (IL\u20101<jats:italic>\u03b2<\/jats:italic>\u2010) induced expression of MMP\u20101, MMP\u20103, and MMP\u201013in chondrocytes by blocking nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) signaling pathways. Furthermore, we found that acacetin suppressed OA progression and inhibited the expression of MMP\u20101, MMP\u20103, and MMP\u201013 in ACLT\u2010induced OA mice. Taken together, our study revealed that acacetin may serve as a potential drug for treating OA.<\/jats:p>","DOI":"10.1155\/2020\/2328401","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:05:19Z","timestamp":1603929919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acacetin Suppresses IL\u20101<i>\u03b2<\/i>\u2010Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF\u2010<i>\u03ba<\/i>B Signaling Pathways"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jian","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangmao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-3941","authenticated-orcid":false,"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-0839","authenticated-orcid":false,"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"30007","article-title":"Osteoarthritis year in review 2019: epidemiology and therapy","volume":"20","author":"Kloppenburg M.","year":"2020","journal-title":"Osteoarthritis and Cartilage"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1393-5"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000246468.80635.ef"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21359"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7542.639"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/OAJSM.S61865"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3046"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.05.005"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1454-2"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01104-z"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01092-0"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01037-7"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0751-z"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1571"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.08.015"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.12.012"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0398-0"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36435"},{"key":"e_1_2_10_20_2","article-title":"Matrix metalloproteinases: a challenging paradigm of cancer management","volume":"16","author":"Alaseem A.","year":"2017","journal-title":"Seminars in Cancer Biology"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.005"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.03.003"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0291-1"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.25002"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.01.002"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2012.700346"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.002"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.10.005"},{"key":"e_1_2_10_30_2","first-page":"869","article-title":"Developing anti-inflammatory therapeutics for patients with osteoarthritis","volume":"6","author":"Philp A. 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