{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:49:16Z","timestamp":1760161756001,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiaxing Science and Technology Project","award":["2017AY33078"],"award-info":[{"award-number":["2017AY33078"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Maternal exercise is crucial for promoting the health of the offspring. Previous studies showed that long\u2010term maternal exercise improves energy metabolism during pregnancy. Whether swimming exercise can reverse the metabolic disorders caused by high\u2010fat exposure in the early life of the offspring is yet to be elucidated. Three\u2010week\u2010old C57BL\/6 female mice were randomly assigned to the standard chow diet group (SC), standard chow diet and exercise group (SC\u2010Ex), high\u2010fat diet group (HFD), and high\u2010fat diet and exercise group (HFD\u2010Ex). After swimming intervention for 13 weeks, male and female mice were caged, and the exercise intervention lasted until delivery. Then, the mothers were fed standard chow diet. A total of 8 offsprings\/group were randomly selected after 4 weeks of lactation for GTT and ITT. After body composition analysis, the mice were sacrificed to obtain specimens. The levels of metabolism factors and IL\u20106 were measured by suspension microarray. Subsequently, 15\u2009min after starting the GTT and ITT, the curve detected significant difference between the HFD and other groups. The body fat percentage of the HFD\u2010Ex offspring was significantly lower than that of HFD offspring (<jats:italic>p<\/jats:italic> &lt; 0.05) irrespective of the gender. The levels of IL\u20106 and TG in the male offspring in the HFD\u2010Ex group were improved significantly (<jats:italic>p<\/jats:italic> &lt; 0.05). Compared to the HFD offspring, serum glucose and GIP in the female offspring in the HFD\u2010Ex group was significantly reduced (<jats:italic>p<\/jats:italic> &lt; 0.05). Long\u2010term exercise of the mother effectively improved the metabolic disorder caused by high\u2010fat exposure in the infant offspring. Thus, the metabolic inheritance of the offspring is gender\u2010dependent; the maternal metabolism can make male offspring genetically susceptible.<\/jats:p>","DOI":"10.1155\/2020\/2358391","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T23:31:09Z","timestamp":1591659069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of High\u2010Fat Diet and Exercise Intervention on the Metabolism Regulation of Infant Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-6404","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4204-9"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.14.38"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2405"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0432"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2019-0387"},{"key":"e_1_2_9_6_2","first-page":"6828","article-title":"Long-term exercise improves metabolism during pregnancy in high-fat fed mice","volume":"12","author":"Zhu X. 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