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Chromebox protein homolog 3 (CBX3) as a member of the heterochromatin-associated protein 1 (HP1) family has been reported to be overexpressed in human cancer tissues. Numerous studies have shown the relationship between the CBX3 expression and clinicopathological factor or prognosis in malignant tumors, but their results are inconsistent. To address these results, a meta-analysis was described to investigate the prognostic value and clinicopathological significance of CBX3 expression in human malignant neoplasms. Methods. PubMed, Web of Science, Embase, and Chinese National Knowledge Infrastructure (CNKI) were used to search eligible literatures, including publications prior to September 2019. The role of CBX3 in cancer prognosis and clinicopathological characteristics was assessed by pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs). Results. Eleven studies with 1682 cancer patients were enrolled in this meta-analysis. This analysis demonstrated that the patients\u2019 increased CBX3 expression was significantly associated with poor overall survival (OS) (univariate analysis: <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>HR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1.81<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI 1.46-2.25; multivariate analysis: <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>HR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.95<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% CI 1.63-2.34). Subgroups analysis by tumor type also indicated that high expression of CBX3 was correlated with poor OS in tongue squamous cell carcinoma (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>HR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>3.31<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI 2.03-5.39), lung cancer (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>HR<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>1.66<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, 95% CI 1.21-2.29), genitourinary cancer (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>HR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>2.03<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, 95% CI 1.15-3.58), and digestive cancer (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>HR<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>1.48<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, 95% CI 1.23-1.79). For clinicopathological features, high expression of CBX3 was associated with lymph node metastasis (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>OR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>2.96<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, 95% CI 1.42-6.20) and lager tumor size (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mtext>OR<\/o:mtext>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>1.60<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>, 95% CI 1.12-2.28). Conclusion. The results of this meta-analysis indicated that CBX3 expression may be a novel biomarker for predicting patient prognosis and clinicopathological parameters in multiple human cancer.<\/jats:p>","DOI":"10.1155\/2020\/2412741","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T01:50:09Z","timestamp":1605232209000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathological and Prognostic Significance of CBX3 Expression in Human Cancer: a Systematic Review and Meta-analysis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-8110","authenticated-orcid":true,"given":"Hexin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China"},{"name":"Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China"},{"name":"Laboratory of Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xia","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"},{"name":"School of Clinical Medicine, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabian","family":"Lian","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Fujian Medical University, Fuzhou, China"},{"name":"Department of laboratory medicine, Xiamen Key Laboratory of Genetic Testing, The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-1422","authenticated-orcid":true,"given":"Jun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China"},{"name":"Laboratory of Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"},{"name":"School of Clinical Medicine, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/35020506"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015507"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.278"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.021"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17325211"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2000.10473905"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5969"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.02.043"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3735"},{"issue":"10","key":"12","first-page":"585","article-title":"Clinical significance of expression of CBX3 in colorectal cancer and its possible mechanism","volume":"23","author":"H. 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