{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:47:57Z","timestamp":1774950477140,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,3,6]]},"abstract":"<jats:p>The present study was directed to investigate the effect of precotreatment with (E)-N<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2032<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85\u2009mg\/kg\/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.<\/jats:p>","DOI":"10.1155\/2020\/2432918","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T23:30:23Z","timestamp":1583537423000},"page":"1-15","source":"Crossref","is-referenced-by-count":20,"title":["(E)-N<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2032<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-0391","authenticated-orcid":true,"given":"Anouar","family":"Feriani","sequence":"first","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Khdhiri","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Appliqu\u00e9e \u201cH\u00e9t\u00e9rocycles Corps Gras & Polym\u00e8res\u201d, Facult\u00e9 des Sciences, Universit\u00e9 de Sfax, 3038 Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriam","family":"Tir","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Ecologie, de Biologie et de Physiologie des Organismes Aquatiques, LR18ES41, Facult\u00e9 des Sciences de Tunis, Universit\u00e9 Tunis EL Manar, 2092 Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afoua","family":"Elmufti","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Tlili","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur des Sciences et Technologies de l\u2019Environnement, Universit\u00e9 de Carthage, Tunisia"},{"name":"D\u00e9partement de Biologie (UR 13\/ES25), Facult\u00e9 des Sciences de Tunis, Universit\u00e9 Tunis El-Manar, Tunis 2092, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raouf","family":"Hajji","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Sidi Bouzid Hospital, Ibn Eljazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houcine","family":"Ammar","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Appliqu\u00e9e \u201cH\u00e9t\u00e9rocycles Corps Gras & Polym\u00e8res\u201d, Facult\u00e9 des Sciences, Universit\u00e9 de Sfax, 3038 Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noureddine","family":"Allouche","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry LR17ES08 (Natural Substances Team), Faculty of Sciences of Sfax, University of Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souhir","family":"Abid","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Appliqu\u00e9e \u201cH\u00e9t\u00e9rocycles Corps Gras & Polym\u00e8res\u201d, Facult\u00e9 des Sciences, Universit\u00e9 de Sfax, 3038 Sfax, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakhdar","family":"Ghazouani","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-6266","authenticated-orcid":true,"given":"Kais","family":"Mnafgui","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Faculty of Sciences of Sfax, University of Sfax, P.O. 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