{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:33Z","timestamp":1789495833487,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o da UFPA"},{"name":"Programa de Apoio \u00e0 P\u00f3s-Gradua\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Par\u00e1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:p><jats:italic>Ganoderma lucidum<\/jats:italic>, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period. In this study, we investigated whether the Aqueous Extract of<jats:italic>G. lucidum<\/jats:italic>(AEGl) reduces the behavioral disorders induced by alcohol. Male (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>30<\/mml:mn><\/mml:math>) and female Wistar rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>40<\/mml:mn><\/mml:math>), seventy-two days old, were used for behavioral\/biochemical and oral toxicity test, respectively. Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3\u2009g\/kg\/day) or distilled water. Twenty-four hours after the last binge administration, animals received AEGl (100\u2009mg\/kg\/day) or distilled water for three consecutive days. After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed. Oxidative stress parameters were measured to evaluate the REDOX balance. Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure. The behavioral effects of the extract were associated to the reequilibrium of the animals\u2019 REDOX balance. Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin.<\/jats:p>","DOI":"10.1155\/2020\/2497845","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T23:31:16Z","timestamp":1596238276000},"page":"1-12","source":"Crossref","is-referenced-by-count":16,"title":["<i>Ganoderma lucidum<\/i>Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking"],"prefix":"10.1155","volume":"2020","author":[{"given":"Chirlene Pinheiro","family":"Nascimento","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra Ara\u00fajo","family":"Luz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Cristiane Soares","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Marques Rosa","family":"Malcher","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luanna Melo Pereira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herta Stutz","family":"Dalla Santa","sequence":"additional","affiliation":[{"name":"State University of Central-West, Department of Food Engineering (DEALI), Cedeteg Campus, Vila Carli, R. Sime\u00e3o Varela de S\u00e1, Guarapuava, 85040-080 Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Rafael Quadros","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-5650","authenticated-orcid":true,"given":"Marta Chagas","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, 66075-900 Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Heitmann Mares Azevedo","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Pharmacy Faculty, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m, PA, 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