{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:15:46Z","timestamp":1788862546712,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1908085MH248"],"award-info":[{"award-number":["1908085MH248"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Triptolide (TP) is the most effective ingredient found in the traditional Chinese herbal <jats:italic>Tripterygium wilfordii<\/jats:italic> Hook F, and it is widely used in therapies of autoimmune and inflammatory disorders. However, the hepatotoxicity induced by TP has restricted its use in clinical trials. Arctiin is known as a protective agent against oxidative stress, and it exerts liver\u2010protecting effect. This study was aimed at investigating the protective role of arctiin against TP\u2010induced hepatotoxicity using <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models. The results indicated that TP not only obviously induced liver injury in mice but also significantly inhibited the growth of HepG2 cells and increased the level of intracellular reactive oxygen. Furthermore, TP obviously decreased the expressions of proteins of Nrf2 pathway including HO\u20101, NQO1, and Nrf2 associated with oxidative stress pathway. However, the above experimental indexes were reversed by the treatment of arctiin. Our results suggested that arctiin could alleviate TP\u2010induced hepatotoxicity, and the molecular mechanism is likely related to its capacity against oxidative stress.<\/jats:p>","DOI":"10.1155\/2020\/2508952","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T01:05:13Z","timestamp":1602983113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Arctiin Antagonizes Triptolide\u2010Induced Hepatotoxicity via Activation of Nrf2 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