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MicroRNAs (miRNAs) can be released into circulation from injured tissues, enticing a potential role as noninvasive biomarkers. We aimed to evaluate circulating levels of miRNA\u201023b, miRNA\u2010143, and miRNA\u2010145 as diagnostic markers of ISR. 142 patients with coronary artery disease undergoing successful angioplasty and a follow\u2010up angiography were included. Subjects were classified according to the degree of obstruction at the angioplasty site into cases (\u226550%) or controls (&lt;50%). Total RNA was isolated from plasma to quantify circulating miRNAs levels, and the ROC curves were constructed. Among circulating miRNAs assessed, miRNA\u201023b and miRNA\u2010143 were significantly lower in cases (miRNA\u201023b: 18.4x10<jats:sup>\u22125<\/jats:sup> and miRNA\u2010143: 13.7x10<jats:sup>\u22125<\/jats:sup>) than controls (miRNA\u201023b: 5.2x10<jats:sup>\u22125<\/jats:sup>, <jats:italic>p<\/jats:italic> &lt; 0.0001; miRNA\u2010143: 4.0x10<jats:sup>\u22125<\/jats:sup>, <jats:italic>p<\/jats:italic> &lt; 0.0001). Plasma levels of miRNA\u2010145 showed no significant differences. The analysis of the ROC curves showed an area under the curve for miRNA\u201023b of 0.71 (95% CI: 0.62\u20100.80, <jats:italic>p<\/jats:italic> &lt; 0.0001) and 0.69 for miRNA\u2010143 (95% CI: 0.60\u20100.78; <jats:italic>p<\/jats:italic> &lt; 0.0001). Our data suggest that plasma levels of miRNA\u201023b and miRNA\u2010143 could be useful as noninvasive biomarkers of ISR.<\/jats:p>","DOI":"10.1155\/2020\/2509039","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T23:30:47Z","timestamp":1600385447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circulating miRNA\u201023b and miRNA\u2010143 Are Potential Biomarkers for In\u2010Stent Restenosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Nicol\u00e1s","family":"Saavedra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Rebolledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Ruedlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Bustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braulio","family":"Bobadilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Lanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5112-6944","authenticated-orcid":false,"given":"Luis A.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.028"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-96445-4_9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304933"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.10.93"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957332"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs115"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101712"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.10.006"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08195"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.197517"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020324"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00153.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.01.001"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1828-2"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.301116"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200912096"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112043"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.745512"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv141"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.308237"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088566"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145930"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/730535"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.10.085"},{"key":"e_1_2_9_25_2","first-page":"765","article-title":"Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer","volume":"8","author":"Wang R. 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