{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:26:59Z","timestamp":1761920819847,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":309,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The purpose of this study was to investigate the efficacy of tranexamic acid (TXA) in patients undergoing open\u2010wedge high tibial osteotomy (OWHTO). Patients from August 2018 to May 2020 were retrospectively studied. Clinical data were obtained including gender, age, height, weight, body mass index (BMI), smoking, alcohol consumption, hypertension, diabetes, history of aspirin, prepostoperative hematocrit (Hct) and hemoglobin (Hb), thrombotic events, blood transfusion requirement, hospital length of stay, size of osteotomy gap, and wound complications such as wound hematoma and infection. 52 patients were enrolled in the tranexamic acid group (TA group), and 48 patients were enrolled in the nontranexamic acid group (NTA group); there were no significant differences between both groups in terms of gender, age, BMI, preoperative Hb, size of osteotomy gap, incidence of smoking, alcohol consumption, hypertension, diabetes, history of aspirin, thrombotic events, blood transfusion requirement, and wound hematoma and infection. The mean hospital length of stay was 9.4 \u00b1 1.0 days in the TA group and 11.0 \u00b1 1.2 days in the NTA group (<jats:italic>P<\/jats:italic> &lt; 0.001), the blood loss was 296.0 \u00b1 128.7\u2009ml in the TA group and 383.3 \u00b1 181.3\u2009ml in the NTA group (<jats:italic>P<\/jats:italic> &lt; 0.05), and the postoperative Hb level was 120.8 \u00b1 15.0\u2009g\/l in the TA group and 109.5 \u00b1 13.8\u2009g\/l in the NTA group (<jats:italic>P<\/jats:italic> &lt; 0.001). In conclusion, the administration of TXA is beneficial to patients undergoing OWHTO via decreasing hospital length of stay, reducing blood loss, and maintaining higher postoperative Hb levels.<\/jats:p>","DOI":"10.1155\/2020\/2514207","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T21:50:09Z","timestamp":1604613009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tranexamic Acid Is Beneficial to Patients Undergoing Open\u2010Wedge High Tibial Osteotomy"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-7560","authenticated-orcid":false,"given":"De-Sheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-3853","authenticated-orcid":false,"given":"Jia-Wang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong-Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Hong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10158-8"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040471"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061382"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43379-0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.01.006"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31460-X"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07856-8"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2012.688725"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967120913531"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-5-65"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2016.03.005"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.11138\/jts\/2016.4.1.006"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1600091"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10143"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007872.pub3"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010562.pub2"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.2165\/11209070-000000000-00000"},{"key":"e_1_2_9_19_2","first-page":"119","article-title":"Varicose vein surgery using a pneumatic tourniquet: reduced blood loss and improved cosmesis","volume":"72","author":"Thompson J. F.","year":"1990","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617714940"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9216"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.2450\/2018.0026-18"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.04.014"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv134"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0772-0"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4829"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8965925"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.5555\/uri:pii:0039606062901666"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198303000-00016"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2019.02.003"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.04.043"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.03.009"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.04.042"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.05.065"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000378"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2018.07.019"},{"key":"e_1_2_9_37_2","first-page":"42","article-title":"The hematological complications of alcoholism","volume":"21","author":"Ballard H. S.","year":"1997","journal-title":"Alcohol Health and Research World"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.02.020"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.182"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2018.07.005"},{"key":"e_1_2_9_41_2","first-page":"198","article-title":"Do obese patients bleed more? A prospective study of blood loss at total hip replacement","volume":"81","author":"Bowditch M. G.","year":"1999","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-010-1205-3"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2767-x"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.05.026"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-012-2087-2"},{"key":"e_1_2_9_46_2","first-page":"168","article-title":"Early motion with cast-brace after modified Coventry high tibial osteotomy","volume":"23","author":"Kriegshauser L. A.","year":"1985","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00554669"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2017.12.006"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.03.039"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/2514207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/2514207.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/2514207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T09:22:14Z","timestamp":1735636934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/2514207"}},"subtitle":[],"editor":[{"given":"Fabiano","family":"Bini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/2514207"],"URL":"https:\/\/doi.org\/10.1155\/2020\/2514207","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2514207"}}