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Cardiovascular disease (CVD) is the leading cause of death in Western civilizations. The type of fatty acid which makes up the diet is related to the cardiovascular morbimortality and the formation of atheromas. Populations with high consumption of oils and fats have a higher number of deaths from CVD. <jats:italic>Purpose<\/jats:italic>. In the present study, the objective was to comparatively analyze the microcirculatory effects of unrefined babassu oil with olive oil in microcirculation and liver of male hamsters of the species <jats:italic>Mesocricetus auratus<\/jats:italic>, checking the permeability to macromolecules after ischemia\u2010reperfusion (I\/R) without and with topical application of histamine 5\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>\u2009M. This is an experimental study, using as model the hamster\u2019s cheek pouch, which was prepared for intravital microscopy. The hamsters were divided into seven groups and orally treated for 14 days, twice a day (at 8 AM and 4 PM), orally received treatments in the following doses: unrefined babassu oil (BO) 0.02\u2009mL\/dose (group BO\u20102), 0.06\u2009mL\/dose (group BO\u20106), and 0.18\u2009mL\/dose (BO\u201018 group); extra virgin olive oil (OI) 0.02\u2009mL\/dose (group OI\u20102), 0.06\u2009mL\/dose (group OI\u20106), and 0.18\u2009mL\/dose (OI\u201018 group); and mineral oil (MO) 0.18\u2009mL\/dose (MO\u201018 group). The observations were made on the 15th day on the hamsters\u2019 cheek pouch; the increase of vascular permeability induced by I\/R with and without histamine application was evaluated, and in the liver the biological material was collected aseptically then fixed in 10% buffered formalin. <jats:italic>Results<\/jats:italic>. Microcirculatory analyses showed a significant reduction in the number of leaks after I\/R with and without the topical use of histamine in animals treated with unrefined BO 0.06\u2009mL\/dose (BO\u20106) and 0.18\u2009mL\/dose (BO\u201018) compared to animals treated with OI. The BO group (<jats:italic>p<\/jats:italic> &lt; 0.001) presented a dose\u2010response relationship for decreasing leaks after I\/R with and without topical use of histamine. Histological liver analyses showed no fat deposition changes in any of the treatment groups. Phytochemical analyses evidenced a chemical compound (C<jats:sub>31<\/jats:sub>H<jats:sub>60<\/jats:sub>NO<jats:sub>8<\/jats:sub>) in unrefined BO but not in OI. <jats:italic>Conclusions<\/jats:italic>. This experiment demonstrates the protective effect of unrefined BO on the microcirculatory system and its greater dose effect than that of OI. Finding a chemical compound (C<jats:sub>31<\/jats:sub>H<jats:sub>60<\/jats:sub>NO<jats:sub>8<\/jats:sub>) that is present in BO but not in OI opens the possibility of investigating whether this chemical compound was responsible for the protective effect on membrane permeability.<\/jats:p>","DOI":"10.1155\/2020\/2525871","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T23:34:51Z","timestamp":1600817691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Babassu (<i>Attalea glassmanii<\/i> Zona) Nut Oil Is More Effective than Olive Oil for Treating Ischemia\u2010Reperfusion Injury"],"prefix":"10.1155","volume":"2020","author":[{"given":"F\u00e1bio Fran\u00e7a","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Signorelli","family":"Balthazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thauany","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim Silva","family":"Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyl Eanes","family":"Barros Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima Zely Garcia de Almeida","family":"Cyrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C\u00e9lia","family":"Pires Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Maria Trindade","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Antonio","family":"Cust\u00f3dio Neto da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Lacerda","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanderson","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Gomes de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boniek Gontijo","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-8252","authenticated-orcid":false,"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-362X","authenticated-orcid":false,"given":"Maria do Desterro Soares Brand\u00e3o","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_9_1_2","article-title":"Reabilita\u00e7\u00e3o cardiovascular, doen\u00e7a arterial coronariana e infarto agudo do mioc\u00e1rdio: efeitos do exerc\u00edcio f\u00edsico","volume":"15","author":"Riberio P. 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