{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:55:54Z","timestamp":1769244954177,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871299"],"award-info":[{"award-number":["81871299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019-I2M-2-005"],"award-info":[{"award-number":["2019-I2M-2-005"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-I2M-1-013"],"award-info":[{"award-number":["2016-I2M-1-013"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    To investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Beh\u00e7et\u2019s disease (BD), we conducted a case\u2010control study on hospitalized BD patients in our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group. The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculosis infection, previous tuberculosis, or without tuberculosis. Finally, we reviewed 386 BD patients and identified 21 (5.4%) ATB cases, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed. We found that BD patients with ATB were more prone to have systemic symptoms (fever, night sweating, and unexplained weight loss) and\/or symptoms related to the infection site. Multivariate logistic regression analysis revealed that erythrocyte\u2009sedimentation\u2009rate\u2009(ESR) &gt; 60\u2009mm\/h (OR = 13.710, 95% CI (1.101, 170.702)), increased IgG (OR = 1.226, 95% CI (1.001, 1.502)), and positive T\u2010SPOT.TB (OR = 7.793, 95% CI (1.312, 48.464), for 24\u2010200 SFC\/10\n                    <jats:sup>6<\/jats:sup>\n                    PBMC; OR = 17.705 95% CI (2.503, 125.260), for &gt;200 SFC\/10\n                    <jats:sup>6<\/jats:sup>\n                    PBMC) were potential risk factors for ATB in BD patients. Our study suggested that when BD patients have systemic symptoms with significantly elevated TB\u2010SPOT, the diagnosis of ATB should be considered.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2528676","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T18:50:29Z","timestamp":1606243829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Features and Risk Factors of Active Tuberculosis in Patients with Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-916X","authenticated-orcid":false,"given":"Yaxu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baotong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-0903","authenticated-orcid":false,"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3165-8185","authenticated-orcid":false,"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2016.1205486"},{"key":"e_1_2_9_2_2","first-page":"38","article-title":"The prevalence of Beh\u00e7et\u2032s disease in Korea: data from Health Insurance Review and Assessment Service from 2011 to 2015","volume":"108","author":"Kim J. 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