{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:41:32Z","timestamp":1762324892832,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":363,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008047","name":"Hebei University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473652","81873251"],"award-info":[{"award-number":["81473652","81873251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To observe the effects of the Huoxue Jiedu Huayu Recipe (HJHR) on pyroptosis of glomerular mesangial cells in the contralateral unobstructed kidney (CK) of unilateral ureteral obstruction (UUO) rats. <jats:italic>Methods<\/jats:italic>. Sprague\u2010Dawley rats were randomly divided into 4 groups: sham group, UUO group (10 days of left ureter ligation), UUO treated with eplerenone (EPL) (UUO\u2009+\u2009EPL) group, and UUO treated with HJHR (UUO\u2009+\u2009HJHR) group. The CKs of all rats were collected for studies. <jats:italic>Results<\/jats:italic>. Cell pyroptosis and macrophage infiltration was found in contralateral glomeruli, and nucleotide\u2010binding oligomerization domain\u2010like pyrin domain containing protein 3 (NLRP3) and interleukin (IL)\u20101<jats:italic>\u03b2<\/jats:italic> expression was upregulated in the CK of UUO rats. All of these changes were inhibited by HJHR and eplerenone. To determine how aldosterone (Aldo) activated the mineralocorticoid receptor (MR) and then induced mesangial cell pyroptosis with NLRP3\u2010caspase\u20101\u2010IL\u20101<jats:italic>\u03b2<\/jats:italic> pathway, human mesangial cells (HMCs) were treated with HJHR and eplerenone, which were examined to detect the expression of NLRP3 inflammasome\u2010associated proteins following treatment with Aldo. <jats:italic>Conclusion<\/jats:italic>. These results suggest that HJHR and eplerenone suppressed HMC pyroptosis via the MR\/NLRP3 pathway.<\/jats:p>","DOI":"10.1155\/2020\/2530431","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T01:50:06Z","timestamp":1609293006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yuxuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1958-6561","authenticated-orcid":false,"given":"Qingyou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.11.011"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00362.2001"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14028"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.114"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.418"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010020143"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000314578"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000154681.38944.9a"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00486.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0498-x"},{"key":"e_1_2_10_11_2","first-page":"515","article-title":"Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen","volume":"51","author":"Taniguchi G. 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