{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:22:40Z","timestamp":1792765360667,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HQ18"],"award-info":[{"award-number":["ZR2016HQ18"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    The aim of this study was to explore the epidemiology of\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    infection in patients with colorectal cancer (CRC) in eastern China. Therefore, 287 primary CRC patients and 287 age\u2010matched healthy control subjects were recruited to estimate the seroprevalence of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    and identify the risk factors of infection. Enzyme\u2010linked immunoassays were used to test for anti\u2010\n                    <jats:italic>T. gondii<\/jats:italic>\n                    immunoglobulin G (IgG) and IgM antibodies. Forty\u2010six (16%) samples were positive for anti\u2010\n                    <jats:italic>T. gondii<\/jats:italic>\n                    IgG antibodies in patients with CRC, compared with 26 (9.1%) in the healthy controls, a significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.007). By contrast, eight (2.8%) patients tested positive for\n                    <jats:italic>T. gondii<\/jats:italic>\n                    IgM antibodies, compared with three (1.1%) in the controls, a difference that was not significant (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.13). Multivariable backward stepwise logistic regression analysis revealed that a rural residence (OR 2.83; 95% CI 1.15\u20137.01;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.024) and treatment with chemotherapy (OR 2.16; 95% CI 1.02\u20134.57;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.045) were risk factors for\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection in patients with CRC. Thus,\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection is serious in patients with CRC, and a rural residence and treatment with chemotherapy are independent risk factors for infection by this parasite. Therefore, medical professionals should be aware of this pathogen in patients with CRC, and the causes of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection in these patients need to be explored further.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2539482","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T14:26:09Z","timestamp":1602080769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased Risk of\n                    <i>Toxoplasma gondii<\/i>\n                    Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case\u2013Control Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-3414","authenticated-orcid":false,"given":"Xiangyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9488-4713","authenticated-orcid":false,"given":"Na","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku305"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.01.009"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1816"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.01.036"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2011.0588"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268818001978"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6604"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268818002194"},{"key":"e_1_2_10_12_2","first-page":"190","article-title":"Toxoplasma 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