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It has been reported that tetrandrine can prevent the development of cardiac hypertrophy by suppressing reactive oxygen species\u2010 (ROS\u2010) dependent signaling pathways in mice. However, whether tetrandrine could attenuate DOX\u2010related cardiotoxicity remains unclear. To explore the protective effect of tetrandrine, mice were orally given a dose of tetrandrine (50\u2009mg\/kg) for 4 days beginning one day before DOX injection. To induce acute cardiac injury, the mice were exposed to a single intraperitoneal injection of DOX (15\u2009mg\/kg). The data in our study showed that tetrandrine prevented DOX\u2010related whole\u2010body wasting and heart atrophy, decreased markers of cardiac injury, and improved cardiac function in mice. Moreover, tetrandrine supplementation protected the mice against oxidative damage and myocardial apoptotic death. Tetrandrine supplementation also reduced ROS production and improved cell viability after DOX exposure in vitro. We also found that tetrandrine supplementation increased nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2) expression and activity in vivo and in vitro. The protection of tetrandrine supplementation was blocked by Nrf2 deficiency in mice. In conclusion, our study found that tetrandrine could improve cardiac function and prevent the development of DOX\u2010related cardiac injury through activation of Nrf2.<\/jats:p>","DOI":"10.1155\/2020\/2616024","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T23:30:29Z","timestamp":1589067029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tetrandrine Attenuated Doxorubicin\u2010Induced Acute Cardiac Injury in Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-2036","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4553-3666","authenticated-orcid":false,"given":"Wen-Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-9257","authenticated-orcid":false,"given":"Ya-Ge","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-2246","authenticated-orcid":false,"given":"Qi-Qiang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-8501","authenticated-orcid":false,"given":"Cheng-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-5189","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107163050305"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.2.1.15"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.2.217"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00795.2008"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.06.1219"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4081\/hi.2012.e3"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230490502601"},{"key":"e_1_2_8_8_2","first-page":"3382","article-title":"Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart","volume":"61","author":"Sun X.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_8_9_2","first-page":"1069","article-title":"Effects of tetrandrine on cardiovascular electrophysiologic properties","volume":"23","author":"Yao W. 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