{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:17:26Z","timestamp":1753881446744,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["XMLX201837"],"award-info":[{"award-number":["XMLX201837"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Felty\u2019s syndrome (FS) is a disorder wherein patients with rheumatoid arthritis develop splenomegaly, neutropenia, and in some cases, portal hypertension without underlying cirrhosis. Esophageal variceal bleeding is a complication of FS in patients with portal hypertension. In contrast to splenectomy, few reports exist on the management of variceal bleeding with endoscopic therapy. Moreover, the long\u2010term outcome has not been reported. We present a patient with esophageal variceal bleeding due to portal hypertension secondary to Felty\u2019s syndrome. The patient was followed up for two years postendoscopy intervention. Literature review was performed and the histological features of portal hypertension in FS are discussed. The patient presented with a typical triad of rheumatoid arthritis (RA), splenomegaly, and neutropenia and was diagnosed as Felty\u2019s syndrome in 2012. She was admitted to our hospital in September 2017 for esophageal variceal bleeding. At the time of admission, her liver function test was normal. Abdominal CT showed no signs of cirrhosis and portal vein obstruction. Liver biopsy further excluded diagnosis of cirrhosis and supported the diagnosis of porto\u2010sinusoidal vascular disease (PSVD), which was previously named as noncirrhotic idiopathic portal hypertension (NCIPH). An upper abdominal endoscopy revealed gastric and esophageal varices. A series of endoscopies was performed to ligate the esophageal varices. The patient was followed up for two years and did not show rebleeding. In conclusion, comorbid PSVD might be a cause of portal hypertension in FS patients. The present case had excellent outcome in two years, which supported the use of endoscopic therapy for the management of variceal bleeding in FS patients. Further large prospective study is needed to confirm the findings.<\/jats:p>","DOI":"10.1155\/2020\/2618260","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T23:31:45Z","timestamp":1593732705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Porto\u2010Sinusoidal Vascular Disease as the Cause of Portal Hypertension in Felty\u2019s Syndrome: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-5756","authenticated-orcid":false,"given":"Song","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Quan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-6688","authenticated-orcid":false,"given":"Calvin Qian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-0035","authenticated-orcid":false,"given":"Huichun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591573803100512"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.6.500"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901408010129"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(91)90002-H"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02939008"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.035"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190204"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160607"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2017.1334816"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.4.393"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10497"},{"key":"e_1_2_10_12_2","article-title":"Longterm effect of methotrexate in Felty\u2032s syndrome: a 12 year followup","volume":"23","author":"Gerster J. 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