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The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. <jats:italic>Materials and Methods<\/jats:italic>. Mice were treated with RSV by gastric tube (320\u2009mg\/kg\/day) or vehicle one week before left coronary artery ligation or sham surgery until the end of the experiments. After pressure\u2013volume loop analysis, mouse hearts were harvested for histopathological (including PSR, TTC, TUNEL staining, immunohistochemistry, and immunofluorescence) and molecular analysis by western blotting and RT-PCR. In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for <jats:italic>in vitro<\/jats:italic> experiments. <jats:italic>Key Findings<\/jats:italic>. RSV treatment decreased mortality and improved cardiac hemodynamics. RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF-<jats:italic>\u03ba<\/jats:italic>B, hence alleviating infarction area, fibrosis, and cell apoptosis. RSV also inhibited expression of interleukin- (IL-) 1<jats:italic>\u03b2<\/jats:italic>, IL-6, tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>, and IL-18 <jats:italic>in vivo<\/jats:italic>. In <jats:italic>in vitro<\/jats:italic> experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. After inhibition of sirtuin 1 (Sirt1) by EX27, RSV failed to inhibit p53 acetylation and expression. Moreover, RSV could inhibit expression of NLRP3 and caspase 1 p20 in NRCMs, CFs, and macrophages, respectively, in in vitro experiments. <jats:italic>Significance<\/jats:italic>. Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1\/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation.<\/jats:p>","DOI":"10.1155\/2020\/2647807","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T23:31:06Z","timestamp":1598398266000},"page":"1-20","source":"Crossref","is-referenced-by-count":75,"title":["Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation"],"prefix":"10.1155","volume":"2020","author":[{"given":"Hong","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-qi","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-0916","authenticated-orcid":true,"given":"Zhou-Yan","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060 RP, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060 RP, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-0005","authenticated-orcid":true,"given":"Hai-han","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311446"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1656450"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.161"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.073"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119452"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074535"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw247"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.01.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13431"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050250"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.008"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001677"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310260"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0374"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8370593"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5989"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2520-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-505-7_18"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0603-8"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.10.001"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-216473"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.270101"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr022"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4175353"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6383"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.06.006"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq376"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5288.782"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/376167a0"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.6.668"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.1.211"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05613.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108586108"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13185"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.020"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00611"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0256"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03418-0"}],"container-title":["Oxidative 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