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In this study, the components in moxa smoke from Jiangxi Poai Biotechnology Co., Ltd., namely, Qing moxa sticks, were absorbed by five solvents (cyclohexane, ethyl acetate, <jats:italic>n<\/jats:italic>\u2010butanol, anhydrous ethanol, and water) and identified by gas chromatography\u2010mass spectrometry. The identification results of the smoke from the Qing moxa sticks that was absorbed in liquid are as follows: a total of 294 compounds were identified, including 139 in cyclohexane, 145 in ethyl acetate, 60 in <jats:italic>n<\/jats:italic>\u2010butanol, 89 in anhydrous ethanol, and 77 in water, and of those, 112 toxic compounds were identified. Furthermore, Ingenuity Pathway Analysis software and the PubChem database were successfully applied to analyze the toxic compounds. There were 812 target proteins related to the toxic components, 25 molecular networks, and 54 biological pathways. The results showed that the toxic compounds of moxa smoke may have some side effects on the heart, liver, and kidney of humans. This study revealed that the components of moxa smoke are complex and diverse. Due to the findings of toxic compounds in moxa smoke, we recommend that moxibustion rooms should be equipped with ventilation equipment or enough artificial ventilation to ensure the health of patients and practitioners.<\/jats:p>","DOI":"10.1155\/2020\/2648759","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T02:05:06Z","timestamp":1604196306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of the Components in Moxa Smoke by GC\u2010MS and Preliminary Discussion on Its Toxicity and Side Effects"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-6505","authenticated-orcid":false,"given":"Xiaoyu","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-6971","authenticated-orcid":false,"given":"Si","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-744X","authenticated-orcid":false,"given":"Wenlei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2014-010688"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x10008275"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-011-0474-8"},{"key":"e_1_2_9_4_2","first-page":"105","article-title":"Research progress on mechanism and safety of moxibustion","volume":"27","author":"Wu J.","year":"2019","journal-title":"Chinese Folk Therapy"},{"key":"e_1_2_9_5_2","first-page":"36","article-title":"Moxa fumigation for 575 surgical infectious conditions (annex: inhibiting bacteria test of the moxa smoke)","volume":"7","author":"Lu Y.","year":"1998","journal-title":"An Hui Zhong Yi Xue Yuan Xue Bao"},{"key":"e_1_2_9_6_2","first-page":"632","article-title":"Research progress on the correlation of artemisinin","volume":"35","author":"Cheng K.","year":"2019","journal-title":"Journal of Practical Chinese Medicine"},{"key":"e_1_2_9_7_2","first-page":"249","article-title":"Diverse biological activities of moxa extract and smoke","volume":"15","author":"Hitosugi N.","year":"2001","journal-title":"In Vivo (Athens, Greece)"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/sga.0b013e3181b2c920"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2017.08.015"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.52.1287"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/178067"},{"key":"e_1_2_9_12_2","first-page":"6","article-title":"Small sample size epidemiological survey of the time-related exposure reaction of acupuncturists under the moxa-smoke environment","volume":"38","author":"Chang Y. 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