{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:54:41Z","timestamp":1792792481145,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673946"],"award-info":[{"award-number":["81673946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313845"],"award-info":[{"award-number":["2017A030313845"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Gastric cancer, one of the most common types of cancers, develops over a series of consecutive histopathological stages. As such, the analysis and research of the gastric precancerous lesions (GPLs) play an important role in preventing the occurrence of gastric cancer. Ginsenoside Rg3 (Rg3), an herbal medicine, plays an important role in the prevention and treatment of various cancers. Studies have demonstrated a correlation between glycolysis and gastric cancer progression. Herein, the aim of the present study was to clarify the potential role for glycolysis pathogenesis in Rg3\u2010treated GPL in Atp4a\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. The GPL mice model showed chronic gastritis, intestinal metaplasia, and more atypical hyperplasia in gastric mucosa. According to the results of HE and AB\u2010PAS staining, it could be confirmed that GPL mice were obviously reversed by Rg3. Additionally, the increased protein levels of PI3K, AKT, mTOR, HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , LDHA, and HK\u2010II, which are crucial factors for evaluating GPL in the aspect of glycolysis pathogenesis in the model group, were downregulated by Rg3. Meanwhile, the miRNA\u201021 expression was decreased and upregulated by Rg3. Furthermore, the increased gene levels of Bcl\u20102 and caspase\u20103 were attenuated in Rg3\u2010treated GPL mice. In conclusion, the findings of this study imply that abnormal glycolysis in GPL mice was relieved by Rg3 via regulation of the expressions of PI3K, AKT, mTOR, HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , LDHA, HK\u2010II, and miRNA\u201021. Rg3 is an effective supplement for GPL treatment and can be harnessed to inhibit proliferation and induce apoptosis of GPL cells.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2672648","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T18:31:07Z","timestamp":1580495467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Panax ginseng<\/i>\n                    C.A. Meyer (Rg3) Ameliorates Gastric Precancerous Lesions in Atp4a\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice via Inhibition of Glycolysis through PI3K\/AKT\/miRNA\u201021 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