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Drug-resistant cancer cells in these hematologic neoplasms are induced by overexpression of the antiapoptotic B-cell lymphoma 2 (Bcl-2) protein families, such as Bcl-XL, Bcl-2, and Mcl-1. We have previously shown that peptides from the BH3 domain of the proapoptotic Bax protein that also belongs to the Bcl-2 family may antagonize the antiapoptotic activity of the Bcl-2 family proteins, restore apoptosis, and induce chemosensitization of tumor cells. Furthermore, cell-permeable Bax BH3 peptides also elicit antitumor activity and extend survival in a murine xenograft model of human B non-Hodgkin\u2019s lymphoma. However, the activity of the BH3 peptides of the proapoptotic Bak protein of the Bcl-2 family against these hematologic malignant cells requires further characterization. In this study, we report the ability of the cell-permeable Bak BH3 peptide to restore apoptosis and induce chemosensitization of acute lymphoblastic leukemia and non-Hodgkin\u2019s lymphoma cell lines, and this event is enhanced with the coadministration of cell-permeable Bax BH3 peptide and represents an attractive approach to improve the patient outcomes with relapsed or refractory hematological malignant cells.<\/jats:p>","DOI":"10.1155\/2020\/2679046","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:20:07Z","timestamp":1606782007000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-417X","authenticated-orcid":true,"given":"Omar","family":"Ugarte-Alvarez","sequence":"first","affiliation":[{"name":"Unit of Investigative Research on Oncological Diseases, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-6288","authenticated-orcid":true,"given":"Paola","family":"Mu\u00f1oz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Unit of Investigative Research on Oncological Diseases, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"},{"name":"Posgrado en Biomedicina y Biotecnolog\u00eda Molecular, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-1499","authenticated-orcid":true,"given":"Liliana Marisol","family":"Moreno-Vargas","sequence":"additional","affiliation":[{"name":"Research Unit on Computational Biology and Drug Design, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-870X","authenticated-orcid":true,"given":"Diego","family":"Prada-Gracia","sequence":"additional","affiliation":[{"name":"Research Unit on Computational Biology and Drug Design, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-4491","authenticated-orcid":true,"given":"Armando Alfredo","family":"Mateos-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Unit of Investigative Research on Oncological Diseases, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-092X","authenticated-orcid":true,"given":"Elayne Irene","family":"Becerra-B\u00e1ez","sequence":"additional","affiliation":[{"name":"Unit of Investigative Research on Oncological Diseases, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"},{"name":"Posgrado en Biomedicina y Biotecnolog\u00eda Molecular, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-6956","authenticated-orcid":true,"given":"Rosendo","family":"Luria-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unit of Investigative Research on Oncological Diseases, Children\u2019s Hospital of Mexico Federico Gomez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01155-5"},{"key":"3","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"S. 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