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In late January 2020, WHO declared the outbreak of a \u201cpublic\u2010health emergency of international concern\u201d due to the rapid and increasing spread of the disease worldwide. Currently, there is no vaccine or approved treatment for this emerging infection; thus, the objective of this study is to design a multiepitope peptide vaccine against COVID\u201019 using an immunoinformatics approach.\n                    <jats:italic>Method<\/jats:italic>\n                    . Several techniques facilitating the combination of the immunoinformatics approach and comparative genomic approach were used in order to determine the potential peptides for designing the T\u2010cell epitope\u2010based peptide vaccine using the envelope protein of 2019\u2010nCoV as a target.\n                    <jats:italic>Results<\/jats:italic>\n                    . Extensive mutations, insertion, and deletion were discovered with comparative sequencing in the COVID\u201019 strain. Additionally, ten peptides binding to MHC class I and MHC class II were found to be promising candidates for vaccine design with adequate world population coverage of 88.5% and 99.99%, respectively.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The T\u2010cell epitope\u2010based peptide vaccine was designed for COVID\u201019 using the envelope protein as an immunogenic target. Nevertheless, the proposed vaccine rapidly needs to be validated clinically in order to ensure its safety and immunogenic profile to help stop this epidemic before it leads to devastating global outbreaks.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2683286","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T19:38:15Z","timestamp":1589225895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Design of a Multiepitope\u2010Based Peptide Vaccine against the E Protein of Human COVID\u201019: An Immunoinformatics Approach"],"prefix":"10.1155","volume":"2020","author":[{"given":"Miyssa I.","family":"Abdelmageed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-8488","authenticated-orcid":false,"given":"Abdelrahman H.","family":"Abdelmoneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-0536","authenticated-orcid":false,"given":"Mujahed I.","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisa M.","family":"Elfadol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem S.","family":"Murshed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaza W.","family":"Shantier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrafie M.","family":"Makhawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.009"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25688"},{"key":"e_1_2_11_4_2","unstructured":"CoV2020 GISAID EpifluDB. 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