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To investigate the serum changes of oxidative stress markers and the relationship between these factors and visual field (VF) progression in patients with primary angle closure glaucoma (PACG). <jats:italic>Methods<\/jats:italic>. A case-control and a prospective cohort study. A total of 94 patients with PACG and 89 normal controls were enrolled. Furthermore, 94 PACG subjects were followed up for at least two years (once every six months). All participants were evaluated for serum levels of superoxide dismutase (SOD), total antioxidant status (TAS), hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), malondialdehyde (MDA), glutathione peroxidase, glutathione reductase, and detailed eye and systematic examination. Binary logistic regression analysis and Cox regression analysis were performed. <jats:italic>Results<\/jats:italic>. The serum levels of SOD and TAS in the PACG group were significantly lower than those in the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Meanwhile, PACG subjects had significantly higher levels of MDA and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> than the normal control subjects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Serum levels of TAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.773<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.349<\/mml:mn><mml:mo>\u2212<\/mml:mo><mml:mn>0.714<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), SOD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.975<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.955<\/mml:mn><mml:mo>\u2212<\/mml:mo><mml:mn>0.995<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), MDA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.155<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.080<\/mml:mn><mml:mo>\u2212<\/mml:mo><mml:mn>1.235<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.216<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.142<\/mml:mn><mml:mo>\u2212<\/mml:mo><mml:mn>1.295<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) were independent risk\/protective factors for PACG. TAS levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.041<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><mml:mo>\u2013<\/mml:mo><mml:mn>0.218<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), SOD levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\"><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.983<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M19\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.971<\/mml:mn><mml:mo>\u2013<\/mml:mo><mml:mn>0.994<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M20\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>), and MDA levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M21\"><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.010<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M22\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.001<\/mml:mn><mml:mo>\u2013<\/mml:mo><mml:mn>1.018<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M23\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:math>) at baseline were associated with visual field progression. Kaplan\u2013Meier curves reveal that patients with <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M24\"><mml:mtext>TAS<\/mml:mtext><mml:mo>&lt;<\/mml:mo><mml:mn>0.95<\/mml:mn><\/mml:math>\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M25\"><mml:mtext>SOD<\/mml:mtext><mml:mo>&lt;<\/mml:mo><mml:mn>143<\/mml:mn><\/mml:math>\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M26\"><mml:mtext>MDA<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>12<\/mml:mn><\/mml:math> had a significantly higher percentage of PACG progression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M27\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Decreased levels of TAS and SOD as well as increased levels of MDA at baseline were associated with VF progression in patients with PACG. These findings suggest that oxidative stress was involved in the onset and development of PACG.<\/jats:p>","DOI":"10.1155\/2020\/2701539","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:34:03Z","timestamp":1596756843000},"page":"1-11","source":"Crossref","is-referenced-by-count":31,"title":["Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-740X","authenticated-orcid":true,"given":"Shengjie","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China"},{"name":"Key Laboratory of 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