{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:40:44Z","timestamp":1776904844235,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catholic University of Maule","award":["1180084"],"award-info":[{"award-number":["1180084"]}]},{"DOI":"10.13039\/501100010599","name":"University of Talca","doi-asserted-by":"crossref","award":["1180084"],"award-info":[{"award-number":["1180084"]}],"id":[{"id":"10.13039\/501100010599","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1180084"],"award-info":[{"award-number":["1180084"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PIEI-QUIBIO Project","award":["1180084"],"award-info":[{"award-number":["1180084"]}]},{"name":"Research Directorate","award":["1180084"],"award-info":[{"award-number":["1180084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,6,22]]},"abstract":"<jats:p>Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor (EGFR), tumor necrosis factor receptor (TNFR), and apoptosis antigen 1 (FAS), causing a reduction of the effects of their respective ligands. In addition, RID inhibits apoptosis by decreasing the secretion of TNF-related apoptosis-inducing ligand (TRAIL) by normal tissue cells. In this article, we report that RID inhibited chemokine expression in human breast cancer cell line MDA-MB-231 but showed no effect in cell line MCF7. These dissimilar results may be due to the different molecular and functional properties of both cell lines. Therefore, it is necessary to replicate this study in other breast cancer cell models.<\/jats:p>","DOI":"10.1155\/2020\/2707635","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T23:33:40Z","timestamp":1592868820000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-<i>\u03b1<\/i> through NF-<i>\u03ba\u03b2<\/i> and AP-1 in Two Cell Lines of Breast Cancer"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-6673","authenticated-orcid":true,"given":"F. A.","family":"Monsalve","sequence":"first","affiliation":[{"name":"Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Perez","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"A\u00f1asco","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Romero","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Araya","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-4200","authenticated-orcid":true,"given":"L. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Asymmetric Synthesis, Institute of Chemistry and Natural Products, University of Talca, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-2983","authenticated-orcid":true,"given":"F.","family":"Delgado-Lopez","sequence":"additional","affiliation":[{"name":"Laboratories of Biomedical Research, Division of Medicine, Universidad Cat\u00f3lica del Maule, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"2","year":"2018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nature04870"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.147765"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071341"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403621101"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2013.0023"},{"key":"8","first-page":"82","volume":"48","year":"2003","journal-title":"Roczniki Akademii Medycznej w Bia\u0142ymstoku"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02698035"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0738"},{"key":"11","first-page":"1","volume":"25","year":"2014","journal-title":"Human Gene Therapy"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.22.11329-11342.2002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008218200"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82001-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02350-05"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.964"},{"issue":"10","key":"17","first-page":"3219","volume":"31","year":"2011","journal-title":"Anticancer Research"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.16.8236-8243.2002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-4-46"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-63"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.59"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00016-8"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.03.018"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3234"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/2707635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/2707635.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/2707635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T23:33:52Z","timestamp":1592868832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2020\/2707635\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":23,"alternative-id":["2707635","2707635"],"URL":"https:\/\/doi.org\/10.1155\/2020\/2707635","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}