{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:58Z","timestamp":1791357058086,"version":"4.3.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007861","name":"University of Gondar","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Peptic ulcer disease causes significant mortality and morbidity. Plant kingdom provides a useful source for the development of new antiulcer agents. <jats:italic>Croton macrostachyus<\/jats:italic> is traditionally used to treat peptic ulcer in Ethiopia. This study aimed to evaluate the antiulcer activity of <jats:italic>C. macrostachyus<\/jats:italic> root extracts in rodents using different models. <jats:italic>Methods<\/jats:italic>. The crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water. The antiulcer activity was evaluated using pylorus ligation\u2010induced ulcer model in Sprague Dawley rats and acidified ethanol\u2010induced ulcer model in Swiss albino mice. The test groups received three doses (100, 200, and 400\u2009mg\/kg) of the crude extract and fractions for 7\u2009days before induction of ulcer. Positive controls received omeprazole 30\u2009mg\/kg for the pylorus ligation\u2010induced ulcer model and sucralfate 100\u2009mg\/kg for the acidified ethanol\u2010induced ulcer model. Negative controls received vehicle (2% tween 80). <jats:italic>Results<\/jats:italic>. The crude hydromethanolic extract of <jats:italic>C. macrostachyus<\/jats:italic> showed significant (<jats:italic>p<\/jats:italic> &lt; 0.05) antiulcer activity on both pyloric ligation and HCl\/ethanol\u2010induced ulcer in rats and mice. It has antisecretary effect (<jats:italic>p<\/jats:italic> &lt; 0.001) as well. All three administered doses of chloroform fraction (<jats:italic>p<\/jats:italic> &lt; 0.05) and only higher doses of ethyl acetate fraction (<jats:italic>p<\/jats:italic> &lt; 0.05) possessed significant antiulcer activity. In contrast, the aqueous fraction did not have significant antiulcer effect at all tested doses. <jats:italic>Conclusion<\/jats:italic>. The present study demonstrated that the crude extract, chloroform, and ethyl acetate fractions possessed significant dose\u2010dependent antiulcer activity.<\/jats:p>","DOI":"10.1155\/2020\/2809270","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T23:30:52Z","timestamp":1586475052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of <i>Croton macrostachyus<\/i> Hocsht: Ex Del. 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