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The mosquito species <jats:italic>Aedes aegypti<\/jats:italic> and <jats:italic>Aedes albopictus<\/jats:italic> are the most frequent transmitters of alphaviruses. There are no effective vaccines or specific antivirals available for the treatment of alphavirus\u2010related infections. Interestingly, changes in ion concentration in host cells have been characterized as critical regulators of the alphavirus life cycle, including fusion with the host cell, glycoprotein trafficking, genome translation, and viral budding. Cardiac glycosides, which are classical inhibitors of the Na<jats:sup>+<\/jats:sup> K<jats:sup>+<\/jats:sup> ATPase (NKA), can inhibit alphavirus replication although their mechanisms of action are poorly understood. Nonetheless, results from multiple studies suggest that inhibition of NKA may be a suitable strategy for the development of alphavirus\u2010specific antiviral treatments. This review is aimed at exploring the role of changes in ion concentration during alphavirus replication and at considering the possibility of NKA as a potential therapeutic target for antiviral drugs.<\/jats:p>","DOI":"10.1155\/2020\/2813253","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T23:30:32Z","timestamp":1589067032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells"],"prefix":"10.1155","volume":"2020","author":[{"given":"Kau\u00ea F. 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