{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:13:29Z","timestamp":1790727209624,"version":"4.1.0"},"reference-count":97,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972571"],"award-info":[{"award-number":["81972571"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472234"],"award-info":[{"award-number":["81472234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901485"],"award-info":[{"award-number":["81901485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>SRY\u2010box transcription factor 2 (SOX2) overlapping transcript (SOX2\u2010OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2\u2010OT gene comprises multiple exons and has multiple transcription start sites and generates hundreds of transcripts. Transcription factors (IRF4, AR, and SOX3), transcriptional inhibitors (NSPc1, MTA3, and YY1), and miRNAs (miR\u2010211 and miR\u2010375) have been demonstrated to control certain SOX2\u2010OT transcript level at the transcriptional or posttranscriptional levels. Accumulated evidence indicates its crucial roles in the regulation of the SOX2 gene, miRNAs, and transcriptional process. Restricted expression of SOX2\u2010OT transcripts in the brain results in the association between SOX2\u2010OT single nucleotide polymorphisms and mental illnesses such as schizophrenia and anorexia nervosa. SOX2\u2010OT is notably elevated in tumor tissues, and a high level of SOX2\u2010OT is well correlated with poor clinical outcomes in cancer patients, leading to the establishment of its role as an oncogene and a prognostic or diagnostic biomarker for cancers. The emerging evidence supports that SOX2\u2010OT mediates diabetic complications. In summary, SOX2\u2010OT has diversified functions and could be a therapeutic target for various diseases.<\/jats:p>","DOI":"10.1155\/2020\/2901589","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T21:05:07Z","timestamp":1606511107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Long Noncoding RNA SOX2\u2010OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications"],"prefix":"10.1155","volume":"2020","author":[{"given":"Pu-Yu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"She-Gan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-0375","authenticated-orcid":false,"given":"Dao-Yin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00196"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1705309"},{"key":"e_1_2_14_3_2","unstructured":"Ensembl genome database (human) 2020 http:\/\/useast.ensembl.org\/Homo_sapiens\/Gene\/Summary?db=core;g=ENSG00000242808;r=3:180989762-181836880."},{"key":"e_1_2_14_4_2","unstructured":"RNACentral 2020 https:\/\/rnacentral.org\/search?q=sox2-ot%20AND%20TAXONOMY:%229606%22%20AND%20rna_type:%22lncRNA%22."},{"key":"e_1_2_14_5_2","unstructured":"Ensembl genome database (mouse) 2020 http:\/\/useast.ensembl.org\/Mus_musculus\/Gene\/Summary?db=core;g=ENSMUSG00000105265;r=3:34104270-34682619."},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1120"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18649-4"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.187"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101881"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109725"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0380-1"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9534"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104283"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1348-2"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0570-7"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2019.4839"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1143-7"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0237-9"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.08.032"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0840-2"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.05.015"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1213"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.02.051"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2026"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7000"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10254"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32827"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.045"},{"key":"e_1_2_14_29_2","unstructured":"Genotype-tissue expression (GTEx) project 2020 https:\/\/www.gtexportal.org\/home\/gene\/SOX2-OT."},{"key":"e_1_2_14_30_2","unstructured":"Human cell landscape (HCL) project 2020 https:\/\/db.cngb.org\/HCL\/index.html."},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2016-0238"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13847"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3981"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.06.004"},{"key":"e_1_2_14_35_2","first-page":"4008","article-title":"Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis","volume":"8","author":"Shi X. M.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_14_36_2","first-page":"5035","article-title":"LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer","volume":"8","author":"Zhang Y.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_14_37_2","first-page":"4482","article-title":"High expression of long noncoding RNA Sox2ot is associated with the aggressive progression and poor outcome of gastric cancer","volume":"20","author":"Zou J. H.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1681"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S169823"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.12.017"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.05.038"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8725"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12188"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1764"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01375"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176889"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2018.0103"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9684703"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27280"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.08.008"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000220"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna5010012"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12575-018-0086-5"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246981"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247005"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.11.009"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201812_16509"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102140"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28917"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.108"},{"key":"e_1_2_14_61_2","first-page":"3841","article-title":"LncRNA SOX2 overlapping transcript acts as a miRNA sponge to promote the proliferation and invasion of Ewing\u2032s sarcoma","volume":"11","author":"Ma L.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S168654"},{"key":"e_1_2_14_63_2","first-page":"6361","article-title":"The SOX2OT\/miR-194-5p axis regulates cell proliferation and mobility of gastric cancer through suppressing epithelial-mesenchymal transition","volume":"16","author":"Wei R.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.05.017"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0737-1"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180579"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.22074\/cellj.2016.3811"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.23464"},{"key":"e_1_2_14_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0512-x"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0309-3"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07862-y"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04362-x"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27145-2"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.11.008"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0333-3"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007640"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3973"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32349"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.029"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3570"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0307-5"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby140"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-018-1942-8"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0147-3"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0042-6"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0236-1"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185355"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy327"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.11.007"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12421"},{"key":"e_1_2_14_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4901-9"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-181325"},{"key":"e_1_2_14_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1542"},{"key":"e_1_2_14_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4135-2"},{"key":"e_1_2_14_95_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5618"},{"key":"e_1_2_14_96_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169232"},{"key":"e_1_2_14_97_2","first-page":"279","article-title":"Enhanced expression of long non-coding RNA Sox2ot promoted cell proliferation and motility in colorectal cancer","volume":"107","author":"Liu S.","year":"2016","journal-title":"Minerva Medica"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/2901589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/2901589.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/2901589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:35:54Z","timestamp":1735630554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/2901589"}},"subtitle":[],"editor":[{"given":"Hong Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/2901589"],"URL":"https:\/\/doi.org\/10.1155\/2020\/2901589","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2901589"}}