{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:07:11Z","timestamp":1787314031750,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:00:00Z","timestamp":1584748800000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRP8F0571"],"award-info":[{"award-number":["CMRP8F0571"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8F1081"],"award-info":[{"award-number":["CMRPG8F1081"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Myasthenia gravis (MG) is an immune\u2010mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Eighteen patients with mild to moderate MG participated in this study. The training group underwent home\u2010based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory\u2010Short Form (MFSI\u2010SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12\u2010week RMT.\n                    <jats:italic>Results<\/jats:italic>\n                    . The 12\u2010week RMT significantly increased forced vital capacity (FVC) from 77.9 \u00b1 12.6\n                    <jats:italic>%<\/jats:italic>\n                    to 83.8 \u00b1 17.7\n                    <jats:italic>%<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03), forced expiratory volume in one second (FEV1) from 75.2 \u00b1 18.3\n                    <jats:italic>%<\/jats:italic>\n                    to 83.3 \u00b1 19.0\n                    <jats:italic>%<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002), and 6\u2010minute walking distance from 403.4 \u00b1 72.2\u2009m to 466.1 \u00b1 68.5\u2009m (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003). The QMG score improved from 9.6 \u00b1 4.1 to 8.1 \u00b1 4.3 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) and the MGC scale from 4.4 \u00b1 3.5 to 2.7 \u00b1 2.9 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02). The fatigue score (MFSI\u2010SF) reduced from 17.1 \u00b1 14.7 to 13.5 \u00b1 16.9 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The home\u2010based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short\u2010term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.\n                  <\/jats:p>","DOI":"10.1155\/2020\/2923907","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T19:30:56Z","timestamp":1584819056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single\u2010Center Hospital\u2010Based Prospective Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-7700","authenticated-orcid":false,"given":"Che-Wei","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Chen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ru","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-3458","authenticated-orcid":false,"given":"Yu-Jih","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Chung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Chang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-8569","authenticated-orcid":false,"given":"Wei-Che","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Neng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Chih","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-3930","authenticated-orcid":false,"given":"Cheng-Hsien","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-5121","authenticated-orcid":false,"given":"Nai-Wen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.011"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10378"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn152"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.55.1.16"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/808607"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.09.001"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1524"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.01.001"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.003"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.07.010"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.2.943"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0329-0"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.94.3.361"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08071130"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282fe96bd"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004856"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_11_18_2","first-page":"359","article-title":"A stepwise approach to the interpretation of pulmonary function tests","volume":"89","author":"Johnson J. 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