{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:43:13Z","timestamp":1781664193426,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":341,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cyprus Institute of Neurology and Genetics"},{"name":"University of Nicosia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative disease, affecting the elderly at a high incidence. AD is of unknown etiology and currently, no cure is available. Present medication is restricted to treating symptoms; thus, a need exists for the development of effective remedies. Medicinal plants constitute a large pool, from which active compounds of great pharmaceutical potential can be derived. Various <jats:italic>Salvia<\/jats:italic> spp. are considered as neuroprotective, and here, the ability of <jats:italic>Salvia fruticosa<\/jats:italic> (SF) to protect against toxic effects induced in an AD cell model was partly assessed. Two of AD\u2019s characteristic hallmarks are the presence of elevated oxidative stress levels and the cytotoxic aggregation of amyloid beta (A<jats:italic>\u03b2<\/jats:italic>) peptides. Thus, we obtained SF extracts in three different solvents of increasing polarity, consecutively, to evaluate (a) their antioxidant capacity with the employment of the free radical scavenging assay (DPPH<jats:sup>\u2022<\/jats:sup>), of the ferric reducing ability of plasma assay (FRAP), and of the cellular reactive oxygen species assay (DCFDA) and (b) their neuroprotective properties against A<jats:italic>\u03b2<\/jats:italic><jats:sub>25\u201335<\/jats:sub>\u2010induced cell death with the use of an MTT assay. All three SF extracts showed a considerable antioxidant capacity, with the methanol (SFM) extract being the strongest. The results of the total phenolic and flavonoid contents (TPC and TFC) of the extracts and of the FRAP and the DCFDA assays showed a similar pattern. In addition, and most importantly, the dichloromethane (SFD) and the petroleum ether (SFP) extracts had an effect on A<jats:italic>\u03b2<\/jats:italic> toxicity, exhibiting a significant neuroprotective potential. To our knowledge, this is the first report of SF extracts demonstrating neuroprotective potential against A<jats:italic>\u03b2<\/jats:italic> toxicity. In combination with their antioxidant capacity, SF extracts may be beneficial in combating AD and other neurodegenerative diseases.<\/jats:p>","DOI":"10.1155\/2020\/2975284","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T19:11:36Z","timestamp":1607454696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta\u2010Induced 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