{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:01:49Z","timestamp":1780578109892,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,11,2]]},"abstract":"<jats:p>Background. To analyze the blood flow changes of radial peripapillary capillaries (RPCs) and macula with time procession in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by optical coherence tomography angiography (OCT-A). Methods. A total of 21 affected eyes and 19 unaffected eyes from 21 NAION patients were included. Assessments of BCVA, CFP, SD-OCT, and OCT-A were performed on NAION patients at enrollment and at 1-2 weeks, 1-2 months, and 3\u20136 months after enrollment. Measures of the thickness of the peripapillary retinal nerve fiber layer (wRNFL) and macular ganglion cell complex (wGCC) of the whole image in SD-OCT, vessel density of the RPC (wRPC) and superficial and deep vascular complexes (wSVD, wDVD) in the whole image of OCT-A, and their superior- and inferior-hemi values (s\/iRNFL, s\/iGCC, s\/iRPC, and s\/iSVD) were assessed. Results. Compared to unaffected control eyes, wRPC (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>\u2264<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) was significantly lower in affected eyes at baseline, and there was no significant difference in wSVD (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&gt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The wRPC and wSVD values of affected eyes were significantly decreased at follow-up time points of 1\u20132 and 3\u20136 months compared to baseline (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>\u2264<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>\u2264<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>\u2264<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). The sRPC values were significantly lower than iRPC at 1-2\/3\u20136 months (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.016<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.013<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>), and sSVD values were lower than iSVD at 1-2 months (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.010<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>). Statistically significant correlations were found between wRPC and wRNFL values at 3\u20136 months (r\u2009=\u20090.626, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.022<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>), between wSVD and wGCC at 1-2 weeks and 1-2 months (r\u2009=\u20090.570, r\u2009=\u20090.436; <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.007<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>p<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.048<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>). Conclusion. OCT-A revealed a sectorial reduction in vessel density in the RPC and macula with the disease progression of NAION from acute to atrophic stages, a classification associated with structural deficits.<\/jats:p>","DOI":"10.1155\/2020\/3010631","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:35:07Z","timestamp":1604363707000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Peripapillary and Macular Flow Changes in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) by Optical Coherence Tomography Angiography (OCT-A)"],"prefix":"10.1155","volume":"2020","author":[{"given":"Juejun","family":"Liu","sequence":"first","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-552X","authenticated-orcid":true,"given":"Changzheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohuizi","family":"Yi","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.11.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.05.027"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2015.1136654"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.05.042"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200204000-00009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-018-0846-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.07.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001259"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22996"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0911-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22021"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9632647"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000489226"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0805-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/wno.0000000000000470"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-1007-8"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309245"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2016.09.020"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22712"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/wno.0000000000000345"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3425-8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9300"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2697-0"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.001"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/srep42201"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.5.10"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000839"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21461"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.11.016"},{"key":"30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ajo.2019.06.009","article-title":"Differentiating veins from arteries on optical coherence tomography angiography by identifying deep capillary plexus vortices","volume":"207","author":"X. 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