{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:30:59Z","timestamp":1784691059544,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-MS-388"],"award-info":[{"award-number":["2019-MS-388"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970501"],"award-info":[{"award-number":["81970501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) infection is the strongest risk factor for gastric cancer (GC). However, the mechanisms of <jats:italic>Hp<\/jats:italic>\u2010associated GC remain to be explored. <jats:italic>Methods<\/jats:italic>. The gene expression profiling (GSE111762) data were downloaded from the GEO database. Differentially expressed genes (DEGs) between normal samples (NO) and <jats:italic>Hp<\/jats:italic>\u2010atrophic gastritis (GA) or <jats:italic>Hp<\/jats:italic>\u2010GA and <jats:italic>Hp<\/jats:italic>\u2010GC were identified by GEO2R. Gene Ontology and pathway enrichment analysis were performed using the DAVID database. lncRNA\u2010TF\u2010mRNA and ceRNA regulation networks were constructed using Cytoscape. The cross\u2010networks were obtained by overlapping molecules of the above two networks. GSE27411 and GSE116312 datasets were employed for validation. <jats:italic>Results<\/jats:italic>. DEGs between NO and <jats:italic>Hp<\/jats:italic>\u2010GA are linked to the activity of inward rectifying potassium channels, digestion, etc. DEGs between <jats:italic>Hp<\/jats:italic>\u2010GA and <jats:italic>Hp<\/jats:italic>\u2010GC were associated with digestion, positive regulation of cell proliferation, etc. According to the lncRNA\u2010TF\u2010mRNA network, 63 lncRNAs, 12 TFs, and 209 mRNAs were involved in <jats:italic>Hp<\/jats:italic>\u2010GA while 16 lncRNAs, 11 TFs, and 92 mRNAs were contained in the <jats:italic>Hp<\/jats:italic>\u2010GC network. In terms of the ceRNA network, 120 mRNAs, 18 miRNAs, and 27 lncRNAs were shown in <jats:italic>Hp<\/jats:italic>\u2010GA while 72 mRNAs, 8 miRNAs, and 1 lncRNA were included in the <jats:italic>Hp<\/jats:italic>\u2010GC network. In the cross\u2010network, we found that immune regulation and differentiation regulation were important in the process of NO\u2010GA. Neuroendocrine regulation was mainly related to the process of GA\u2010GC. In the end, we verified that CDX2 plays an important role in the pathological process of NO to <jats:italic>Hp<\/jats:italic>\u2010GA. Comparing <jats:italic>Hp<\/jats:italic>\u2010GA with <jats:italic>Hp<\/jats:italic>\u2010GC, DEGs (FPR1, TFF2, GAST, SST, FUT9, and SHH), TF, and GATA5 were of great significance. <jats:italic>Conclusions<\/jats:italic>. We identified the DEGs, and their lncRNA regulatory network of <jats:italic>Hp<\/jats:italic>\u2010associated diseases might provide insights into the mechanism between <jats:italic>Hp<\/jats:italic> infection and GC. Furthermore, in\u2010depth studies of the molecules might be useful to explore the multistep process of gastric diseases.<\/jats:p>","DOI":"10.1155\/2020\/3012193","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T05:17:42Z","timestamp":1605676662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with <i>Helicobacter pylori<\/i>\u2010Associated Diseases including Atrophic Gastritis and Gastric Cancer"],"prefix":"10.1155","volume":"2020","author":[{"given":"Songyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aining","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-9036","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-2165","authenticated-orcid":false,"given":"Yuehua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.026"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311685"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32610"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13222"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220636"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00085-X"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652306775515501"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920210793175895"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.146704"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051410-092902"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-38"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)89318-C"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8797"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7215"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101444"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29384"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13165"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-844"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-8-20"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10021"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj021"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-5-p3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg034"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt432"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp517"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2011.05.002"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2011.06.010"},{"key":"e_1_2_9_30_2","first-page":"22","article-title":"Late results of surgical treatment in patients, suffering complicated forms of chronic pancreatitis","volume":"12","author":"Ratchyk V. 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