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Traditional invasive hemoglobin (Hb) detection led to delayed diagnosis, operational inefficiency, incorrect critical decision making, and uncomfortable patient experience. To facilitate real-time total hemoglobin (tHb) monitoring, a portable prototype of a noninvasive Hb detection system was developed, and the accuracy of Hb predicted based on partial least squares (PLS) as well as backpropagation artificial neural network (BP-ANN) models was validated. <jats:italic>Results<\/jats:italic>. The prototype was combined with a signal processing circuit and a spectrophotometric probe containing 8 wavelength LEDs light source and photodiode array. Laboratory invasive Hb (Lab_tHb) and spot check Hb measurements with PLS (SpHb_PLS) and BP (SpHb_BP) methods were obtained simultaneously by hematology analyzer and the designed system. The invasive and noninvasive estimates of the Hb levels were analyzed using Spearman correlation as well as Bland\u2013Altman plot and receiver operating characteristic (ROC) curve analysis. A total of 238 volunteers had attempted laboratory invasive and noninvasive spot check Hb measurements. Mean Lab_tHb, SpHb_PLS, and SpHb_BP were 13.6\u2009\u00b1\u20091.80\u2009g\/dL, 13.5\u2009\u00b1\u20091.07\u2009g\/dL, and 13.6\u2009\u00b1\u20091.06\u2009g\/dL, respectively. Noninvasive SpHb_PLS (<jats:italic>r<\/jats:italic>\u2009=\u20090.61, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and SpHb_BP (<jats:italic>r<\/jats:italic>\u2009=\u20090.62, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) had a strong correlation with invasive tHb values. The Bland\u2013Altman plot showed excellent consistency between the proposed noninvasive methods and laboratory invasive reference. In ROC analysis, PLS and BP models were good at predicting Hb\u2009\u2265\u200912\u2009g\/dL with area under the curve of 0.828 and 0.824, respectively. Observed differences between invasive and noninvasive Hb measurements displayed no significant correlation with perfusion index values. <jats:italic>Conclusions<\/jats:italic>. The result confirmed that noninvasive Hb monitoring had an excellent correlation with traditional invasive Hb measurement. Furthermore, it is suggested that the developed prototype has the potential for the noninvasive detection of Hb concentration with the methods of PLS and BP-ANN.<\/jats:p>","DOI":"10.1155\/2020\/3034260","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T18:30:19Z","timestamp":1579372219000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration"],"prefix":"10.1155","volume":"2020","author":[{"given":"Hongyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing 100853, China"},{"name":"Center of Medical Device R & D and Clinical Evaluation, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulai","family":"Peng","sequence":"additional","affiliation":[{"name":"Shandong 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