{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:52:05Z","timestamp":1791219125275,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":343,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The <jats:italic>Anacardium occidentale<\/jats:italic> L. (cashew) and <jats:italic>Anacardium microcarpum<\/jats:italic> D. (caju\u00ed) are plants commonly found in Brazil. They present phytochemical compounds with antioxidant and anti\u2010inflammatory action. Therefore, the objective of this study was to analyze the antioxidant and anti\u2010inflammatory activities of ethanolic extracts from leaves of <jats:italic>A. occidentale<\/jats:italic> and <jats:italic>A. microcarpum<\/jats:italic> and its effect on the hepatic tissue in experimental knockout models after they received Paracetamol\u00ae. <jats:italic>Methods<\/jats:italic>. Ethanol extracts from <jats:italic>A. occidentale<\/jats:italic> and <jats:italic>A. microcarpum<\/jats:italic> leaves were prepared. Total phenolics were determined by Folin\u2013Ciocalteau reagent, and flavonoids are based on the complexation reaction with the aluminum metal, forming a colored complex. Fingerprint HPLC was performed to detect phenolic compounds. Knockout IL\u201010 mice randomly divided into six groups were used and received the following treatments: G1, only water; G2, <jats:italic>A. occidentale<\/jats:italic> extract; G3, <jats:italic>A. microcarpum<\/jats:italic> extract; G4, Paracetamol\u00ae; G5, Paracetamol\u00ae\u2009+\u2009<jats:italic>A. occidentale<\/jats:italic> extract (400\u2009mg\/kg); G6, Paracetamol\u00ae\u2009+\u2009<jats:italic>A. microcarpum<\/jats:italic> extract (400\u2009mg\/kg). Biochemical parameters of the blood and differential count of leukocytes were done. Oxidative markers and histopathological analyses were performed on their liver tissue. <jats:italic>Results<\/jats:italic>. Phenolic compounds and total flavonoids were detected in both two extracts analyzed. The HPLC fingerprint detected phenolic acid, gallic acid, and catechin flavonoid in the two extracts. Histopathological analyses of the hepatic tissue permitted evaluation of nuclear increase, sinusoid congestion, and inflammatory infiltrate. <jats:italic>A. microcar<\/jats:italic>pum presented more antioxidant activity increasing antioxidant enzyme levels and reducing TBARS and carbonyl protein when compared to the other treatments after exposure to Paracetamol\u00ae. Histopathological analyses showed a decrease in the inflammatory infiltrate after treatment with extracts. <jats:italic>Conclusion<\/jats:italic>. Our findings indicate that both extracts, especially <jats:italic>A. microcarpum<\/jats:italic>, can reduce hepatic damage in knockout mice exposed to paracetamol, indicating the curative power of these extracts reducing lipid peroxidation and in the morphofunctional damage to the liver parenchyma.<\/jats:p>","DOI":"10.1155\/2020\/3054521","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T08:10:33Z","timestamp":1607587833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antioxidant and Anti\u2010Inflammatory Effects of <i>Anacardium occidentale<\/i> L. and <i>Anacardium microcarpum<\/i> D. Extracts on the Liver of IL\u201010 Knockout Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5039","authenticated-orcid":false,"given":"Anderson Barbosa","family":"Baptista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-7877","authenticated-orcid":false,"given":"Mari\u00e1urea M.","family":"Sarandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-3590","authenticated-orcid":false,"given":"Reggiani Vilela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-5328","authenticated-orcid":false,"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-4013","authenticated-orcid":false,"given":"Cl\u00e1udio","family":"Gon\u00e7alves da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-4424","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Viana","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4665-7043","authenticated-orcid":false,"given":"Maria do Carmo Gouveia","family":"Peluzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-8661-72"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.02.021"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3753562"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090465"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.25066\/agrotec.v36i1.23002"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-84782004000400017"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/824185"},{"key":"e_1_2_9_8_2","first-page":"369","volume-title":"Handbook of Experimental Pharmacology","author":"Hinson J. A.","year":"2010"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00422.2005"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2012.00835.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12223"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2693-8"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.017400"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.01.006"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000468"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080660"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030834"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.10.031"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215576299"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9060511"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.09.009"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195786"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.11.021"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20161915"},{"key":"e_1_2_9_25_2","first-page":"115","article-title":"Concept of stadardization, extraction and pre phytochemical screening strategies for herbal drug","volume":"2","author":"Pandey A.","year":"2014","journal-title":"Journal of Pharmacy Phytochemistry"},{"key":"e_1_2_9_26_2","volume-title":"Antioxidantes. Princ\u00edpios e M\u00e9todos Anal\u00edticos","author":"Boroski M.","year":"2015"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf100128b"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.38212\/2224-6614.2748"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1590\/1809-4392201501045"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR2020.7025"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-695x2006000100012"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1516-93322008000400025"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00722.x"},{"key":"e_1_2_9_34_2","volume-title":"The Manual of Cytotechnology","author":"Keebler C. M.","year":"1993"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1678-4456.v53i2p138-145"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0748-5514(85)90028-5"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-h"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.003"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/59.3.365"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02284.x"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.9734\/IJR2H\/2019\/46466"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2004.7.495"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6919834"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3807234"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8394818"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2016.03.004"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00295"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502009000300008"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2017.v10i3.15937"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.09.017"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.06.100"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2014.03.001"},{"key":"e_1_2_9_56_2","first-page":"88","article-title":"Herbal extracts differentially inhibit oxidative effects caused by the biotransformation of nifurtimox , nitrofurantoin and acetaminophen on rat liver microsomes","volume":"16","author":"Letelier M. E.","year":"2017","journal-title":"Bolet\u00edn Latinoam y del Caribe Plantas Med y Arom\u00e1ticas."},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v4i2.31194"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1143825"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.022"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040758"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194426"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.18511\/rbcm.v13i3.648"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.5604\/16652681.1193701"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311425059"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800535"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.06.025"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12183"},{"key":"e_1_2_9_69_2","first-page":"72","article-title":"Evaluation of antioxidant potential of methanolic leaf extract of Anacardium occidentale (Linn) on the testes of streptozotocin-induced diabetic wistar rats","volume":"17","author":"Ukwenya V.","year":"2013","journal-title":"European Journal of Anatomy"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7817360"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8376081"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02915.x"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.909"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-015-0030-4"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.04.011"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/3054521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/3054521.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/3054521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:02:50Z","timestamp":1723021370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/3054521"}},"subtitle":[],"editor":[{"given":"Abraham","family":"Wall Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/3054521"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3054521","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3054521"}}