{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:06Z","timestamp":1787017746190,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["BE2016789"],"award-info":[{"award-number":["BE2016789"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171077"],"award-info":[{"award-number":["BK20171077"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["81670570"],"award-info":[{"award-number":["81670570"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["81700572"],"award-info":[{"award-number":["81700572"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BE2016789"],"award-info":[{"award-number":["BE2016789"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171077"],"award-info":[{"award-number":["BK20171077"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81670570"],"award-info":[{"award-number":["81670570"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81700572"],"award-info":[{"award-number":["81700572"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BE2016789"],"award-info":[{"award-number":["BE2016789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20171077"],"award-info":[{"award-number":["BK20171077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670570"],"award-info":[{"award-number":["81670570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700572"],"award-info":[{"award-number":["81700572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BE2016789"],"award-info":[{"award-number":["BE2016789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20171077"],"award-info":[{"award-number":["BK20171077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670570"],"award-info":[{"award-number":["81670570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700572"],"award-info":[{"award-number":["81700572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,2,28]]},"abstract":"<jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    . Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery.\n                    <jats:italic>Methods<\/jats:italic>\n                    . The association of AR expression with liver regeneration was studied in the rat small-for-size liver transplantation model and the mice major hepatectomy and hepatic IR injury model with or without fatty change. The direct role and mechanism of AR in liver regeneration was explored in the AR knockout mouse model.\n                    <jats:italic>Results<\/jats:italic>\n                    . Delayed regeneration was detected in fatty liver after liver surgery in both rat and mouse models. Furthermore, the expression of AR was increased in liver after liver surgery, especially in fatty liver. In a functional study, the knockout of AR promoted liver regeneration at day 2 after major hepatectomy and IR injury. Compared to wild-type groups, the expressions of cyclins were increased in normal and fatty livers of AR knockout mice. AR inhibition increased the expressions of PPAR-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and PPAR-\n                    <jats:italic>\u03b3<\/jats:italic>\n                    in both normal liver and fatty liver groups after major hepatectomy and IR injury. In addition, the knockout of AR promoted the expressions of SDHB, AMPK, SIRT1, and PGC1-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    in liver, which regulated mitochondrial biogenesis and energy metabolism.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The knockout of AR promoted the regeneration of normal and fatty livers through regulating energy metabolism. AR may be a new potential therapeutic target to accelerate liver regeneration after surgery.\n                  <\/jats:p>","DOI":"10.1155\/2020\/3076131","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T18:31:32Z","timestamp":1582914692000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-3534","authenticated-orcid":true,"given":"Chang Xian","family":"Li","sequence":"first","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang Jie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-9895","authenticated-orcid":true,"given":"Yao Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen Huan","family":"Luo","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-7332","authenticated-orcid":true,"given":"Xiang Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04724.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7194"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225113.88433.cf"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27619"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.022"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/1389557515666150909143737"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.02.023"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/srep42199"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0568fje"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1650com"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/1389450120666191007111712"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01012.2008"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000429"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/963629"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2715"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.04.021"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.053"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20969"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28054"},{"issue":"4","key":"21","first-page":"316","volume":"2","year":"2003","journal-title":"Cell Cycle"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8510-y"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35276"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(01)00119-X"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065644"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072013"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801791200"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.10.005"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22421"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20075"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.060"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000228867.98158.d2"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.010352"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.025"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.031"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6895"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/3076131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/3076131.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/3076131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T18:31:37Z","timestamp":1582914697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/3076131\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":36,"alternative-id":["3076131","3076131"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3076131","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]}}}