{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:16:13Z","timestamp":1787235373163,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"\n Background<\/jats:italic>\n . Gestational diabetes mellitus (GDM) is a severe threat to the health of both mother and child. The pathogenesis of GDM remains unclear, although much research has found that the levels of hydrogen sulfide (H\n 2<\/jats:sub>\n S) play an important role in complications of pregnancy.\n Methods<\/jats:italic>\n . We collected venous blood samples from parturient women and umbilical vein blood (UVB) and peripheral venous blood (PVB) samples one hour after childbirth in the control, GDM-, and GDM+ groups in order to determine the concentration of glucose and H\n 2<\/jats:sub>\n S in plasma; to measure levels of TNF-\n \u03b1<\/jats:italic>\n , IL-1\n \u03b2<\/jats:italic>\n , IL-6, TGF-\n \u03b2<\/jats:italic>\n 1, and ADP in parturient women and the UVB of newborns; and to find the correlation of H\n 2<\/jats:sub>\n S with regression.\n Results<\/jats:italic>\n . We found that, with the elevation of glucose, the level of H\n 2<\/jats:sub>\n S was decreased in GDM pregnant women and newborns and the concentrations of IL-6 and TNF-\n \u03b1<\/jats:italic>\n were upregulated. With regression, IL-6 and TNF-\n \u03b1<\/jats:italic>\n concentrations were positively correlated with the level of blood glucose and negatively correlated with H\n 2<\/jats:sub>\n S concentration.\n Conclusion<\/jats:italic>\n . This study shows that downregulation of H\n 2<\/jats:sub>\n S participates in the pathogenesis of GDM and is of great significance in understanding the difference of H\n 2<\/jats:sub>\n S between normal and GDM pregnant women and newborns. This study suggests that IL-6 and TNF-\n \u03b1<\/jats:italic>\n are correlated with gestational diabetes mellitus. The current study expands the knowledge base regarding H\n 2<\/jats:sub>\n S and provides new avenues for exploring further the pathogenesis of GDM.\n <\/jats:p>","DOI":"10.1155\/2020\/3085840","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T19:30:53Z","timestamp":1584991853000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Expression of H\n 2<\/sub>\n S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-\n \u03b1<\/i>"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yucui","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-9139","authenticated-orcid":true,"given":"Shuxia","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-3592","authenticated-orcid":true,"given":"Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-5463","authenticated-orcid":true,"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2324-0309","authenticated-orcid":true,"given":"Jinjing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Laboratory, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-8966","authenticated-orcid":true,"given":"Qian","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second People\u2019s Hospital of Liaocheng, Linqing, Shandong Province, 252600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"B19","DOI":"10.2337\/diacare.21.3.C19","volume":"21","year":"1998","journal-title":"Diabetes Care"},{"issue":"2","key":"2","first-page":"173","volume":"22","year":"2009","journal-title":"Journal of Nephrology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041951"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001631"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000096"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12631"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.04.021"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.01.013"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2018.01.007"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123894"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00533"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00398.2011"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.11r01cp"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.903565"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13914"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.03.010"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2975"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1990.hed3004201.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12590"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1435-3"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2020\/3085840.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2020\/3085840.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2020\/3085840.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T19:30:58Z","timestamp":1584991858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jdr\/2020\/3085840\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":21,"alternative-id":["3085840","3085840"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3085840","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]}}}